DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and ubp4

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001342719.1	Gene:	ubp4 / 2540837	PomBaseID:	SPBC18H10.08c	Length:	593	Species:	Schizosaccharomyces pombe

Alignment Length:	492	Identity:	105/492 - (21%)
Similarity:	189/492 - (38%)	Gaps:	129/492 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KHNVALELS-------------------HGTL-YCYACRDFIYDARSREYALINR----KLE--- 117
            ||.:|:.:|                   |.:: .||:...:..|. |..|.|.:.    ||:
pombe   143 KHTIAIPISCLQSMDSSKIYDFLKSAPFHPSMVICYSLERYFEDV-SLAYKLYSMLRSLKLDPHF 206

  Fly   118 -----AKDLQKSIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQAL- 176
                 .|.:..|:.:..:.|.                         ||.|||.||:|||::|.|
pombe   207 MELANPKKVDSSLSYENYQPI-------------------------GLTNLGNTCYMNCVLQCLF 246

  Fly   177 ----VHTPLLSD----YFMSDRHDCGSKSSHKCLVCEVSRLFQEFYS---------GSRSPLSLH 224
                :..|:|..    ..::.::..|:.          .::...|:|         |.|| :|..
pombe   247 ACKDLTIPMLQGRGLLQNINTKNPLGTG----------GKITSAFFSLLQSVLLNHGQRS-ISPR 300

  Fly   225 RLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSS- 288
            ..|.::.:..:..:...|.||.||....||.||         .:..||:|.|.....:.:..|:
pombe   301 NFLEIVQSLNRDFSIDGQCDAQEFLNFFLDKLH---------EDLNSNASRSPIAPLTEDQLSAR 356

  Fly   289 ---------------HCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTH 338
                           |.....:.:::. |.|.|.|...|..|...|||:.||..:::.: :..:|
pombe   357 EELPLSHFSHIEWNLHLRSNKSIVVNN-FVGQLCSRTQCMTCGRTSTTFAPFTSLAIPI-DDVSH 419

  Fly   339 GGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSAL-- 401
                ..:|.:||.:::..|.|.......|..||..:.:.|...:..||..:...::||:.|.:
pombe   420 ----VVSLQECLLKFSAPELLQGHDGWHCPVCKVQRSAKKVIMISKLPEYLIIQIQRFKISVMGR 480

  Fly   402 --IDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVK 464
              ||..:...:|.|.:. :.|...:....|....::|:|.:.|.|.::.|||.:.|....: |..
pombe   481 KKIDTPLGLSLQIPSKM-LVPPSFQSGIGYIPSNYNLFAFICHYGQLENGHYISDVLFNNE-WCH 543

  Fly   465 CDDHVI-TMASLKQVLD--SEGYLLFYHKNVL--EYE 496
            .||.:: |:..:..:.:  |..|:|||.::.|  |:|
pombe   544 IDDSIVRTVGGITDLREDFSSSYILFYKRSSLLEEFE 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	7/42 (17%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	85/371 (23%)
ubp4	NP_001342719.1	COG5533	156..574	CDD:227820	98/471 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940