DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp32

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_011247292.1	Gene:	Usp32 / 237898	MGIID:	2144475	Length:	1618	Species:	Mus musculus

Alignment Length:	513	Identity:	120/513 - (23%)
Similarity:	197/513 - (38%)	Gaps:	139/513 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YFGCRG---------AHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRK---- 115
            |.||..         .:::..||.|:.::.|.|.:...|.....|   :....||..|..:
Mouse   652 YTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLWLYNSENYLTLLDD---EDHRLEYLKIQDEQHLV 713

  Fly   116 LEAKDLQKSIGWVPWVPTTKETNLLLANARR--RLVRPNQTIGLRGLLNLGATCFMNCIVQALVH 178
            :|.::  |.:.|       .|....:||:.:  |...|.:. |..||.|||.|||||..:|.:.:
Mouse   714 IEVRN--KDMSW-------PEEMSFIANSSKIDRHKVPTEK-GATGLSNLGNTCFMNSSIQCVSN 768

  Fly   179 TPLLSDYFMSDRH--------DCGSKSSH--KCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNH 233
            |..|:.||:|.||        ..|.| .|  ||    ...|.||.:||::..::..:|...|..:
Mouse   769 TQPLTQYFISGRHLYELNRTNPIGMK-GHMAKC----YGDLVQELWSGTQKNVAPLKLRWTIAKY 828

  Fly   234 AKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESK----SNSSGSGSGTNSSNSSSSHCYGQC 294
            |....|::|||:.|.....||.||....:.   ||..    .:|.|......::.:..:|.....
Mouse   829 APRFNGFQQQDSQELLAFLLDGLHEDLNRV---HEKPYVELKDSDGRPDWEVAAEAWDNHLRRNR 890

  Fly   295 NCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLG-ETTTH--------GGVTP-----KT 345
            :.::| :|.|.|:|.|.|:.|..:|..:|||..:||.|. ::..|        .|.||     :.
Mouse   891 SIVVD-LFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPIRYGLRL 954

  Fly   346 LIDCLERYT------------RAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFE- 397
            .:|  |:||            ::|.: ..|::..|..|::.:..::..|.     ||..|..||
Mouse   955 NMD--EKYTGLKKQLSDLCGLKSEQI-LFAEVHSSNIKNFPQDNQKVRLS-----VSGFLCAFEI 1011

  Fly   398 --------HSALIDRKISS--------------------FIQFPVEFDMTPFMSEKKNAYGDFRF 434
                    ..:.|....||                    ||...:...:.|..:||....|
Mouse  1012 PIPASPVSACSPIQTDCSSSPSTNGLFTLTTNGDLPRPIFIPNGMPNTVVPCGTEKNVTNG---- 1072

  Fly   435 SLYAVVN-HVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKN 491
                :|| |:..:....:|.|:                :|..::::.:|.|.|...||
Mouse  1073 ----IVNGHMPPLPDDPFTGYI----------------IAVHRKMMRTELYFLSSQKN 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	10/47 (21%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	96/400 (24%)
Usp32	XP_011247292.1	FRQ1	189..339	CDD:227455
		UBP12	518..1330	CDD:227847	120/513 (23%)
		UCH	<1248..1578	CDD:366104
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940