DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp3

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_006511173.1	Gene:	Usp3 / 235441	MGIID:	2152450	Length:	606	Species:	Mus musculus

Alignment Length:	501	Identity:	149/501 - (29%)
Similarity:	233/501 - (46%)	Gaps:	68/501 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RDARERKA----IHCNCFECGSYGIQLYACLHCIYFGCRGAHITSHLRSKK-----HNVALELSH 89
            |..|..|:    :.|:...||.| :..:|..|   :......:.:|.||:|     |.|.::.|.
Mouse   116 RVCRSNKSPWVCLTCSSVHCGRY-VNGHAKKH---YEDAQIPLLNHKRSEKQEKAQHTVCMDCSS 176

  Fly    90 GTLYCYACRDFIYDARSREYALINRKLE-AKDLQKSIGWVPWVPTTKETNLLLANA--RRRLVRP 151
            .:.|||.|.||:  ....:..|:.:..| .::|:.|    .:.........||.|:  ..:|::.
Mouse   177 YSTYCYRCDDFV--VNDTKLGLVQKVREHLQNLENS----AFTADRHRKRKLLENSSLNSKLLKV 235

  Fly   152 N---QTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYF-------MSDRHDCGSKSSHK------ 200
            |   ..|...||.|||.|||||.|:|:|.:......||       :.:....|.::.|.
Mouse   236 NGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDS 300

  Fly   201 --CLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKA 263
              .||.|..:.....:.||::..|...|.:::|....:..||:|||||||....||.||.
Mouse   301 NVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHL----- 360

  Fly   264 KAEHESKSNSSG-SGSGTNSSNS----SSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYD 323
                |.:...:| |.|.....||    |:..|....:.::..||.|:||::|.|..|...|..:|
Mouse   361 ----ELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 421

  Fly   324 PFWDISLDL--------GETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQF 380
            ||.|:|||:        .:...:|.|.  :|.|||..:|..|.|.......|..||..|:|||:|
Mouse   422 PFLDLSLDIPSQFRSKRSKNQENGPVC--SLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKF 484

  Fly   381 SLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGD-FRFSLYAVVNHV 443
            .::.||..:..|||||..:|.:..|:.:::|||:. .||..::.|.:|:..| ..:.|.|||.|.
Mouse   485 WIQKLPKALCLHLKRFHWTAYLRNKVDTYVQFPLRGLDMKCYLLEPENSGPDSCLYDLAAVVVHH 549

  Fly   444 GT-IDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            |: :.:||||||..|: ..|...:|..:|:...:.|..::.|:|||
Mouse   550 GSGVGSGHYTAYAVHE-GRWFHFNDSTVTVTDEETVGKAKAYILFY 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	18/61 (30%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	117/362 (32%)
Usp3	XP_006511173.1	zf-UBP	117..191	CDD:366940	21/79 (27%)
Usp3	XP_006511173.1	UCH	245..594	CDD:366104	115/360 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D929408at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850