DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP24

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_016856320.1	Gene:	USP24 / 23358	HGNCID:	12623	Length:	2640	Species:	Homo sapiens

Alignment Length:	421	Identity:	96/421 - (22%)
Similarity:	153/421 - (36%)	Gaps:	114/421 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 TKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSS 198
            |||.:.|..      |....:.|..||.|.||||:||.:.|.|...|.|.:..:|...|  :.:.
Human  1691 TKEFDYLPP------VDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDD--TDNP 1747

  Fly   199 HKCLVCEVSRLFQEFYSGSRS---PLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHC 260
            ...:..:|..||.........   |.:..::..: ||  |.|...|||||:|||.:.:|.:..:.
Human  1748 DDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKM-WN--KELYVREQQDAYEFFTSLIDQMDEYL 1809

  Fly   261 VKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPF 325
            .|...:.                             |....|.|:.....:|:.|.......:.|
Human  1810 KKMGRDQ-----------------------------IFKNTFQGIYSDQKICKDCPHRYEREEAF 1845

  Fly   326 WDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVS 390
              ::|:||.|:.      ::|...|:::.|.|.|..:....|..||..:.:.|:..:::||||:.
Human  1846 --MALNLGVTSC------QSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLV 1902

  Fly   391 FHLKRF----EHSALIDRKISSFIQFPVEFDMTPFM--------------------------SEK 425
            .||.||    |....|  |....|:||...:|.|:.                          |.:
Human  1903 IHLMRFGFDWESGRSI--KYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVDQGGGGSPR 1965

  Fly   426 KNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ----KDTWVKCDDHVITMASLK-QVLDSE--- 482
            |.......:.|..|:.|.|....|||.::::.:    |..|.|.:|.||....|. :.|:.|
Human  1966 KKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFG 2030

  Fly   483 -----------------------GYLLFYHK 490
                                   .|:|||.:
Human  2031 GEYRPKVYDQTNPYTDVRRRYWNAYMLFYQR 2061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	89/394 (23%)
USP24	XP_016856320.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910