Protein Alignment not and USP22

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_056091.1
• Gene: USP22 / 23326
• HGNCID: 12621
• Length: 525
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 275/536 - (51%)
• Similarity: 353/536 - (65%)
• Gaps: 57/536 - (10%)

  Fly   202 DASSAVMSETGCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYAC 266
            ||..|| :..||.|..|:..::.....|.|...|......:||:|||..|.|..||.:..:|::|
Human    13 DAELAV-APPGCSHLGSFKVDNWKQNLRAIYQCFVWSGTAEARKRKAKSCICHVCGVHLNRLHSC 76

  Fly   267 LHCIYFGC-RGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQ- 329
            |:|::||| ...||..|.::|:||:|::|.:|.:||:.|:|:|||   ::..:|.::.:.|..:
Human    77 LYCVFFGCFTKKHIHEHAKAKRHNLAIDLMYGGIYCFLCQDYIYD---KDMEIIAKEEQRKAWKM 138

  Fly   330 KSIG--WVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDY 392
            :.:|  :..|.||.:|..||..|.:||.:..|.|||||||:|||.|||||||||||.|||||.|:
Human   139 QGVGEKFSTWEPTKRELELLKHNPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDF 203

  Fly   393 FMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFI 457
            |:||||.|..:|...|||||:|.||||||||.|||...::||||:|.||:|||||||||||||.|
Human   204 FLSDRHRCEMQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLI 268

  Fly   458 ATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQAC 522
            |.||||||||             .|..:|..::|.:      .|||||||||||.|||||.||.|
Human   269 AALDVLHRHC-------------KGDDNGKKANNPN------HCNCIIDQIFTGGLQSDVTCQVC 314

  Fly   523 NGVSTTYDPFWDISLDL-GETTTHGGVTP----------------KTLIDCLERYTRAEHLGSAA 570
            :|||||.|||||||||| |.:|....::|                .||.|||.|:||.|||||:|
Human   315 HGVSTTIDPFWDISLDLPGSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSA 379

  Fly   571 KIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNA 635
            |||||.|.||||||||.:::.||.|..||||||||||.:.|||::::.||:|.||||||:..|.:
Human   380 KIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKES 444

  Fly   636 -------------YGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLD 687
                         ..|.::||:|||||.||:::||||:::|..||.|.||||.:||.||:|.|||
Human   445 RMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLD 509

  Fly   688 SEGYLLFYHKNVLEYE 703
            ||||||||||..||||
Human   510 SEGYLLFYHKQFLEYE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	24/57 (42%)
		Peptidase_C19D	365..696	CDD:239125	208/360 (58%)
USP22	NP_056091.1	zf-UBP	63..123	CDD:460464	26/62 (42%)
		Peptidase_C19D	176..518	CDD:239125	208/360 (58%)