Protein Alignment not and USP33

DIOPT Version :9

• Sequence 1: NP_001287106.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_055832.3
• Gene: USP33 / 23032
• HGNCID: 20059
• Length: 942
• Species: Homo sapiens
• Alignment Length: 729
• Identity: 153/729 - (20%)
• Similarity: 249/729 - (34%)
• Gaps: 276/729 - (37%)

  Fly     8 HYQSYVKEHSYDTFRVIDAYFAACVNRDA-----RE---RKAIHCNCFECGSYGIQLYACL--HC 62
            |::|..|:....  ..:.|:...|.:.|:     :|   :|::. .|.:|...|..|:|||  .|
Human    18 HFESLGKQEKIP--NKMSAFRNHCPHLDSVGEITKEDLIQKSLG-TCQDCKVQGPNLWACLENRC 79

  Fly    63 IYFGCRGA---HITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKS 124
            .|.||..:   |.|.|.:..||.:.:.|:...::||||...::                  |.:.
Human    80 SYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVF------------------LDRK 126

  Fly   125 IGWVPWVPTTKETNLLLANARRRLVRPNQTI-------------------------GLRGLLNLG 164
            :|..|.:|..::.:.:..|:.:....|:.|.                         ||.||.|:|
Human   127 LGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIG 191

  Fly   165 ATCFMNCIVQALVHTPLLSDYFMSDRHDCG--SKSSHKCLVCE-----VSRLFQEFYSGSRSPLS 222
            .||:||..:|||.:.|.|:.:|:    |||  :::..|..:|:     ::.|:.:...||..|.:
Human   192 NTCYMNAALQALSNCPPLTQFFL----DCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTT 252

  Fly   223 LHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAE--------------HESKSNS 273
            |.:.:..:   .....||.||||.||....:|:||....:...|              .|.||.|
Human   253 LFQGIKTV---NPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQS 314

  Fly   274 -------SGSGSGTNSSNSSSSHCYGQ---------------------------CN--------- 295
                   ....:...:.|.:.|.|:.:                           ||
Human   315 DVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEG 379

  Fly   296 ----------------------------------------------------------------- 295
                                                                             
Human   380 EFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSG 444

  Fly   296 ----------------------------CIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISL-- 330
                                        .:|..||.|.:.|.|.|..|:.||.|.:.|.|:||
Human   445 NLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPI 509

  Fly   331 ----DLGE--TTTH----------------------------------------GGVTPKTLIDC 349
                ||.:  :::|                                        |.|.  ||.||
Human   510 PGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVV--TLQDC 572

  Fly   350 LERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPV 414
            |..:...:.|.......|..||..:...|...::..|.::..|||||.|..:...|||:.:.||:
Human   573 LAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPL 637

  Fly   415 E-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ-KDTWVKCDDHVITMASLKQ 477
            | .|:.||:::...|. ...:.|.:|:.|.||..:|||.||.|:. .:.|.:.||..:|..|...
Human   638 EGLDLQPFLAKDSPAQ-IVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSEST 701

  Fly   478 VLDSEGYLLFYHKN 491
            |.::|.|:|||.|:
Human   702 VQNAEAYVLFYRKS 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	21/61 (34%)
		Peptidase_C19D	158..489	CDD:239125	113/537 (21%)
USP33	NP_055832.3	zf-UBP	61..121	CDD:280334	21/59 (36%)
		UCH	184..712	CDD:278850	113/537 (21%)
		Peptidase_C19	186..>288	CDD:271592	35/108 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..357		7/62 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..469		0/49 (0%)
		Peptidase_C19R	473..713	CDD:239139	68/242 (28%)
		DUSP	734..803	CDD:299905
		DUSP	840..924	CDD:197831

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910