Protein Alignment not and Usp49

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_940813.1
• Gene: Usp49 / 224836
• MGIID: 2685391
• Length: 685
• Species: Mus musculus
• Alignment Length: 650
• Identity: 150/650 - (23%)
• Similarity: 224/650 - (34%)
• Gaps: 219/650 - (33%)

  Fly   253 CFECGSYGIQLYACLHCIYFGCRGA----HITSHLRSKKHNVALELSHGTLYCYACRDFI----- 308
            |.:|.:.. ..:|||.|.:..| |.    |...|.....|.:|:|:....::||.|:|::
Mouse    26 CLQCATTE-SAWACLKCSHVAC-GRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNP 88

  Fly   309 ----------------------------------------------------------------- 308
                                                                             
Mouse    89 EGDLKLLRSSLLAVRGQKQDLLARRGRTLRSTAAGEDVVPPQRTPQGQPQMLTALWYRRQRLLAK 153

  Fly   309 ---------------YDARSREYALINRKLEAKDLQKSI------------------------GW 334
                           .:.|.:|.||..:|..|:..::.:                        |.
Mouse   154 TLRLWFQKSSRGRAQLEQRRQEEALERKKEAARQRRREVKRRLLEELASAPPRKSARLLLHAPGP 218

  Fly   335 VPWVPTTKETNLLLA----NARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVH---------- 385
            |...|.|..|:..|:    |.||   :|....|:.||.|||.||:||.|:|.|.|
Mouse   219 VAVRPATLATSRRLSAAALNPRR---QPAVAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLN 280

  Fly   386 -TPLLSDYF----------MSDRHDCGS------------------------------------- 402
             .|..|::.          :|.|....|
Mouse   281 LDPSTSEHLFPQATNGKAQLSGRPASSSAAELSVRSVRAQGCEPQGLCWSSGASISRSLELIQNK 345

  Fly   403 --KSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHR 465
              .|.|..|..|:..||:..:||..:.:|...:||.:|:......||:||||.||.   .::||
Mouse   346 EPSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFL---CELLH- 406

  Fly   466 HCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYD 530
                 |.:.|.:|..|........|....:.   |...:::.||.|.|.|.|.|.:||..|.|.:
Mouse   407 -----KVQQELESEGSTRRILIPFSQRKLTK---QVLKVVNTIFHGQLLSQVTCISCNYKSNTIE 463

  Fly   531 PFWDISLDLGET--TTHGGVTPKTLIDC-----LERYTRAEHLGSAAKIKCSTCKS--------- 579
            ||||:||:..|.  ....|..|....:|     |.::|..|.| ......|..|.|
Mouse   464 PFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSNPKP 527

  Fly   580 --YQESTKQFSLRTLPSVVSFHLKRFEHSALIDR-KISSFIQFPVEFDMTPFMSEKKNAYGD--- 638
              ..|:.||..:..||.|:..|||||..|....| ||...:.|.....|.|:......:..|
Mouse   528 LVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVIFDQVLTMEPYCCRDMLSSLDKET 592

  Fly   639 FRFSLYAVVNHVGT-IDTGHYTAYVRH-QKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLE 701
            |.:.|.|||.|.|. ..:||||||..: :...||.|:|..:.:.|:::|..::.|:|||.:..::
Mouse   593 FAYDLSAVVMHHGKGFGSGHYTAYCYNTEGGFWVHCNDSKLDVCSVEEVCKTQAYILFYTRRTVQ 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	17/145 (12%)
		Peptidase_C19D	365..696	CDD:239125	115/414 (28%)
Usp49	NP_940813.1	zf-UBP	26..87	CDD:460464	17/62 (27%)
		UCH	250..651	CDD:425685	114/413 (28%)