DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp22

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001004143.2	Gene:	Usp22 / 216825	MGIID:	2144157	Length:	525	Species:	Mus musculus

Alignment Length:	526	Identity:	272/526 - (51%)
Similarity:	348/526 - (66%)	Gaps:	56/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGC-R 68
            ||.|..|:..::.....|.|...|......:||:|||..|.|..||.:..:|::||:|::||| .
Mouse    22 GCSHLGSFKVDNWKQNLRAIYQCFVWSGTAEARKRKAKSCVCHVCGIHLNRLHSCLYCVFFGCFT 86

  Fly    69 GAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQ-KSIG--WVPW 130
            ..||..|.:||:||:|::|.:|.:||:.|:|:|||   ::..:|.::.:.|..: :.:|  :..|
Mouse    87 KKHIHDHAKSKRHNLAIDLMYGGIYCFLCQDYIYD---KDIEIIAKEEQRKAWKMQGVGEKFSTW 148

  Fly   131 VPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGS 195
            .||.:|..||..|.:||.:..|.|||||||:|||.|||||||||||.|||||.|:|:||||.|..
Mouse   149 EPTKRELELLKHNPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEM 213

  Fly   196 KSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHC 260
            :|...|||||:|.||||||||.|||...::||||:|.||:|||||||||||||.||.||||||||
Mouse   214 QSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHC 278

  Fly   261 VKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPF 325
                         .|..:|..::|.:      .|||||||||||.|||||.||.|:|||||.|||
Mouse   279 -------------KGDDNGKKANNPN------HCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPF 324

  Fly   326 WDISLDL-GETTTHGGVTP----------------KTLIDCLERYTRAEHLGSAAKIKCSTCKSY 373
            ||||||| |.:|....::|                .||.|||.|:||.|||||:||||||.|.||
Mouse   325 WDISLDLPGSSTPFWPLSPGSEGSVVNGESHASGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSY 389

  Fly   374 QESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNA---------- 428
            ||||||.:::.||.|..||||||||||.:.|||::::.||:|.||||||:..|.:
Mouse   390 QESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQYQQPL 454

  Fly   429 ---YGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHK 490
               ..|.::||:|||||.||:::||||:::|..||.|.||||.:||.||:|.|||||||||||||
Mouse   455 DSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLDSEGYLLFYHK 519

  Fly   491 NVLEYE 496
            ..||||
Mouse   520 QFLEYE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	25/57 (44%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	208/360 (58%)
Usp22	NP_001004143.2	zf-UBP	63..123	CDD:396634	27/62 (44%)
Usp22	NP_001004143.2	Peptidase_C19D	176..518	CDD:239125	208/360 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849972
Domainoid	1	1.000	416	1.000	Domainoid score	I657
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52664
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1186
Isobase	1	0.950	-	0	Normalized mean entropy	S2087
OMA	1	1.010	-	-		QHG59954
OrthoDB	1	1.010	-	-		D929408at2759
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		otm43148
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750