DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and math-33

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001294689.1	Gene:	math-33 / 179538	WormBaseID:	WBGene00010406	Length:	1138	Species:	Caenorhabditis elegans

Alignment Length:	528	Identity:	118/528 - (22%)
Similarity:	196/528 - (37%)	Gaps:	140/528 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SETGCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFG 66
            ::.|.||..:.....|...|    .:|..|.|.:..:::.:    :.|  ||..:...|:
Worm    75 NQQGSRHSMNSRVNRSNFNF----GFFLQCNNDELLQKRGM----WRC--YGTAVLEVLN----- 124

  Fly    67 CRGAHITSHLRSKKHNVALE--LSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVP 129
            ..|..|...:....||..::  .|:...|...|       ..::..::|..::.:     ..:..
Worm   125 ADGPSIQKKIHHSFHNTEVDWGFSNYDQYDTLC-------NPKDGYVVNDTIKLR-----CRFTA 177

  Fly   130 WVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSD----- 189
            .|||  ..|.:..:.|.        .|..||.|.||||:||.|:|        |.||.:.
Worm   178 DVPT--GANYMWDSKRH--------TGCIGLRNQGATCYMNSILQ--------SFYFTTGFRRAV 224

  Fly   190 -RHDCGSKSSHKCLVCEVSRLFQEFYSGSRS--PLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIA 251
             ..|.|::.:...:|..:.|:|.|....|.:  ..||.|...  |:   .|..:.|.|..||...
Worm   225 YNMDVGTEPNESNIVLAMQRVFYELQMASEAVETNSLTRAFG--WD---KLDAFNQHDVQEFCRV 284

  Fly   252 TLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACN 316
            .||.|.   .|.|...|.||                          |..:|.|.::|.:.|...:
Worm   285 LLDNLE---TKMKGTSEEKS--------------------------IPNLFRGNMKSYIKCLDVD 320

  Fly   317 GVSTTYDPFWDISLD-LGETTTHGGVTPKTLIDCLER----YTRAEHLGSAAKIKCSTCKSYQES 376
            ..|:..:.|:|:.|: ||             :|.|||    ||.:|.|....|..... ...|.:
Worm   321 YESSRTESFYDVQLNVLG-------------MDSLERAFEAYTTSEILDDENKYDAGD-HGLQRA 371

  Fly   377 TKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMT------PFMSEKKNAYGDFRFS 435
            .|......||.::...|.||::.. :::||:....||.:.::.      |.::|:     |..:|
Worm   372 EKGVKFVELPPILHVQLMRFQYCG-VEQKINERFSFPEKMNLASCCELGPMLTEE-----DCVYS 430

  Fly   436 LYAVVNHVGTIDTGHYTAYVR---HQKDT-------WVKCDDHVITMASL----------KQVLD 480
            |:||:.|.|....|||..|:.   |:...       |.|.||.|::..:.          ::.::
Worm   431 LHAVLVHSGEFHGGHYVTYINVNLHESAVDPTSSAKWCKFDDDVVSRTTTDDAIVSNFGGEKTMN 495

  Fly   481 SEGYLLFY 488
            |..|:|.|
Worm   496 SSAYMLVY 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	11/58 (19%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	92/370 (25%)
math-33	NP_001294689.1	COG5077	4..1136	CDD:227409	118/528 (22%)
		MATH	30..182	CDD:295307	23/135 (17%)
		peptidase_C19C	194..507	CDD:239124	93/372 (25%)
		USP7_ICP0_bdg	636..863	CDD:289221
		USP7_C2	900..1125	CDD:291217
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910