DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and usp-46

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_499162.2	Gene:	usp-46 / 176381	WormBaseID:	WBGene00011216	Length:	426	Species:	Caenorhabditis elegans

Alignment Length:	437	Identity:	108/437 - (24%)
Similarity:	174/437 - (39%)	Gaps:	105/437 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 AKDLQKSIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVH-TPL 181
            :..|:|.|.      ||:..|    ||.....         ||:|.|.||:.|.::|||.. .|.
Worm     6 SSQLEKEIS------TTESVN----NANEHYY---------GLVNFGNTCYCNSVIQALFFCRPF 51

  Fly   182 ---LSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSR--SPLSLHRLLHLIWNHAKHLAGYE 241
               :.:|..:.:....||.:   ||..::.||....|..|  ..::..|.:..:....:....|.
Worm    52 REKVLNYKQTLKKSGASKDN---LVTCLADLFHSIASQKRRVGTIAPKRFITKLKKENELFDNYM 113

  Fly   242 QQDAHEFFIATLDVLHRHCVKAK-AEHE----------------------------SKSNSSGSG 277
            ||||||||...::.:....::.| ||.|                            .|..|..:|
Worm   114 QQDAHEFFNYLINTISETLIQEKIAEREKASRHGTLKKGNVTVNLAPATAGLPRSDEKGTSERNG 178

  Fly   278 ----SGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTH 338
                .|....|.|.:..:      |.:||.|:|.::..|.:|..||:..:.|.|:|:|:.:.|
Worm   179 GITVEGNEFLNKSDTTTW------IHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNT-- 235

  Fly   339 GGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALID 403
                  ::..||..::..|.|....|..|.||.|.||:.|:..::..|.:::.|||||:....::
Worm   236 ------SISHCLRVFSETETLCGDQKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFVEPLN 294

  Fly   404 R--KISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVG-TIDTGHYTAYVRHQKDTWVKC 465
            |  |:|..:.||:|..:  |.......|||..:.|.|.|.|.| |.:.|||...|: ....|:..
Worm   295 RHTKLSYRVVFPLELRL--FNVSDDAEYGDRMYDLVATVVHCGATPNRGHYITLVK-SNSFWLVF 356

  Fly   466 DDHVITMASLKQVLDSEG------------------------YLLFY 488
            ||.::....:..:.:..|                        |:|||
Worm   357 DDDIVEKLEVSSMEEFSGMSTDANIQMPPGNQSAPQKNSESAYILFY 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	100/397 (25%)
usp-46	NP_499162.2	UCH	26..403	CDD:278850	98/405 (24%)
usp-46	NP_499162.2	Peptidase_C19G	28..404	CDD:239128	100/396 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910