DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp-14

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_497006.1	Gene:	usp-14 / 175105	WormBaseID:	WBGene00006856	Length:	489	Species:	Caenorhabditis elegans

Alignment Length:	457	Identity:	86/457 - (18%)
Similarity:	157/457 - (34%)	Gaps:	152/457 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 SIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLR-----GLLNLGATCFMNCIVQALVHTPLLS 183
            |:|.:|..||..|        :::..|..|...:.     ||.|||.||:.|..||.|..   ::
Worm    71 SVGEIPKPPTVLE--------KKQANRDKQAEEISALYPCGLANLGNTCYFNSCVQMLKE---VN 124

  Fly   184 DYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRS------PLSLHRLLHLIWNHAKHLAGYEQ 242
            :..:....:...:..:..|...::.||.......|:      |:.....:..:.:.......::|
Worm   125 ELVLKPAEEMRIREHNDRLCHNLATLFNSLRDKDRALRSKGEPIKPFAAILTLSDSFPQFEKFKQ 189

  Fly   243 QDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQ 307
            |||:|..::.:                               |:.:..||.....|:.:|....:
Worm   190 QDANECLVSIM-------------------------------SNVTRIYGLSGWNIESLFRIQTE 223

  Fly   308 SDVVCQACNGVS----------TTYDPFWDISLDLG--ETTTHGGVTPKTLIDCLERYTR-AEHL 359
            :.:.|...:.||          |.|     ::.|:.  :|....|..        |..|| :|.|
Worm   224 TTMKCLESDEVSEKKVERNNQLTCY-----VNQDVRFLQTGIKAGFE--------EEMTRNSEEL 275

  Fly   360 GSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRF--EHSALIDRKISSFIQFPVEFDMTPFM 422
            ...||        :|::|:   :..||..::.::.||  :.|...:.||...:|||::.|.....
Worm   276 NRDAK--------WQKNTQ---ISRLPKYLTVNINRFFYKESTKTNAKILKSVQFPMQLDTYDLC 329

  Fly   423 SE--------------------------KK------------------NAYGDFR-------FSL 436
            |:                          ||                  .|:.|..       :.|
Worm   330 SQELKDKLVARRADIKLEEDAKLERELRKKVLDKEQGDKIFDDGVALPTAFEDDAGSNNSGFYDL 394

  Fly   437 YAVVNHVG-TIDTGHYTAYVRHQKD-TWVKCDDHVITMASLKQVLDSEG-------YLLFYHKNV 492
            ..::.|.| :...|||.|::|..:| .|...||..:|:...:.:|.:.|       |:|.|...|
Worm   395 KGIITHKGRSSQDGHYVAWMRSSEDGKWRLFDDEHVTVVDEEAILKTSGGGDWHSAYVLLYEARV 459

  Fly   493 LE 494
            ::
Worm   460 IK 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	76/416 (18%)
usp-14	NP_497006.1	UBQ	1..71	CDD:294102	86/457 (19%)
		UBQ	4..71	CDD:214563	86/457 (19%)
		UCH	101..455	CDD:278850	76/411 (18%)
		Peptidase_C19A	103..456	CDD:239122	76/410 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910