DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp33

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_573510.2	Gene:	Usp33 / 170822	MGIID:	2159711	Length:	909	Species:	Mus musculus

Alignment Length:	679	Identity:	146/679 - (21%)
Similarity:	230/679 - (33%)	Gaps:	259/679 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CFECGSYGIQLYACL--HCIYFGCRGA---HITSHLRSKKHNVALELSHGTLYCYACRDFIYDAR 105
            |.:|...|..|:|||  .|.|.||..:   |.|.|.:..||.:.:.|:...::||||...::
Mouse    30 CQDCKVRGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVF--- 91

  Fly   106 SREYALINRKLEAKDLQKSIGWVPWVPTTKETNLLLANARRRLVRPN------------------ 152
                           |.:.:|..|.:|..::......|:.:....|:
Mouse    92 ---------------LDRKLGTPPSLPHVRQPQQTQENSVQDFKIPSNPALKTPMVAVSEDLDIE 141

  Fly   153 -------QTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCG--SKSSHKCLVCE--- 205
                   :..||.||.|:|.||:||..:|||.:.|.|:.:|:    |||  :::..|..:|:
Mouse   142 VEEEDELKARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFL----DCGGLARTDKKPAICKSYL 202

  Fly   206 --VSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAE-- 266
              ::.|:.:...||..|.:|.:.:..:   .....||.||||.||....:|:||....:...|
Mouse   203 KLMTELWHKSRPGSVVPANLFQGIKTV---NPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEME 264

  Fly   267 ------------HESKS-------------------NSSGSGSGTNSSNSSSSHCYGQ------- 293
                        .|.||                   |.|||......||.::.....:
Mouse   265 EEPQTLTSEETVEEEKSQSDVDFQSCESCSSSEKAENESGSKGFPEDSNETTMLIQDEDDLEMAK 329

  Fly   294 -------CN------------------C------------------------------------- 296
                   ||                  |
Mouse   330 DWQKEKVCNKINKANADVELDKDRDTVCETVDLNSQETVKVQIHGRASESITDVHLNDLATSQIL 394

  Fly   297 -----------------------------------------------IIDQIFTGMLQSDVVCQA 314
                                                           :|..||.|.:.|.|.|..
Mouse   395 PSNESVSPRLSASPPKLGSLWPGLSPPHKKAQSTSAKRKKQHKKYRSVISDIFDGTVISSVQCLT 459

  Fly   315 CNGVSTTYDPFWDISL------DLGE--TTTHGGV----------TPK----------------- 344
            |:.||.|.:.|.|:||      ||.:  :::|..:          .|:
Mouse   460 CDRVSITLETFQDLSLPIPGKEDLAKLHSSSHPTIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSC 524

  Fly   345 ----------TLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHS 399
                      ||.|||..:...:.|.......|..||..:...|...::..|.::..|||||.|.
Mouse   525 VPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFRHE 589

  Fly   400 ALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ-KDTW 462
            .:...|||:.:.||:| .|:.||:::...|. ...:.|.:|:.|.||..:|||.||.|:. .:.|
Mouse   590 LMFSTKISTHVSFPLEGLDLQPFLAKDSPAQ-IVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW 653

  Fly   463 VKCDDHVITMASLKQVLDSEGYLLFYHKN 491
            .:.||..:|..|...|.::|.|:|||.|:
Mouse   654 YEFDDQSVTEVSESTVQNAEAYVLFYRKS 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	21/61 (34%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	115/533 (22%)
Usp33	NP_573510.2	zf-UBP	30..90	CDD:366940	21/59 (36%)
		UCH	154..679	CDD:366104	114/532 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..315		10/53 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..436		0/38 (0%)
		DUSP	701..770	CDD:386277
		DUSP	807..891	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910