DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP51

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_958443.1	Gene:	USP51 / 158880	HGNCID:	23086	Length:	711	Species:	Homo sapiens

Alignment Length:	557	Identity:	249/557 - (44%)
Similarity:	330/557 - (59%)	Gaps:	106/557 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TGCRHYQSY-VKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGC 67
            |||.|.:|: |.::.....|:|...|......:.|:|||..|.|..|.::..:|::||.|::|||
Human   193 TGCSHVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSCICHVCSTHMNRLHSCLSCVFFGC 257

  Fly    68 -RGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVPWV 131
             ...||..|..:|:|::|::|.||.:||:.|:|::||               ||:::.      .
Human   258 FTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYD---------------KDIEQI------A 301

  Fly   132 PTTKETNLLLANA---------------------------RRRLVRPNQ--------TIGLRGLL 161
            ..|||..|.|..:                           ..:||:|.:        |:|||||:
Human   302 KETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSVYTVGLRGLI 366

  Fly   162 NLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRL 226
            |||.|||||||||||.|.|||.|:|:||:|.|...|...|||||:|.||...|||||:|...::|
Human   367 NLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSRTPHIPYKL 431

  Fly   227 LHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCY 291
            |||||.||:|||||.|||||||.||.|||||||         ||.:|.|       ..:::.:|
Human   432 LHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRH---------SKDDSGG-------QEANNPNC- 479

  Fly   292 GQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDL-GETTTHGGVTPK----------- 344
              |||||||||||.|||||.||||:.||||.||.||||||| |...|.....|:
Human   480 --CNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDH 542

  Fly   345 -----TLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDR 404
                 :|.|||:.:||.|||||:|||||::|:||||||||.:::.||.|..||||||||.....|
Human   543 IPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRR 607

  Fly   405 KISSFIQFPVEFDMTPFMSEKKNAY------------GDFRFSLYAVVNHVGTIDTGHYTAYVRH 457
            ||::||.||:|.|||||::..|.:.            .:.::||:||:||.||:::||||:::|.
Human   608 KINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQ 672

  Fly   458 QKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLE 494
            |||.|..|||.:||.|:::.:|.||||||||||..||
Human   673 QKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	22/57 (39%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	193/359 (54%)
USP51	NP_958443.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..174
		zf-UBP	236..296	CDD:280334	24/74 (32%)
		UCH	362..703	CDD:278850	193/359 (54%)
		Peptidase_C19D	363..704	CDD:239125	193/359 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I655
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1213
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59954
OrthoDB	1	1.010	-	-		D200191at33208
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		otm41077
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840