DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp2

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_446226.3	Gene:	Usp2 / 115771	RGDID:	621073	Length:	618	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	140/428 - (32%)
Similarity:	194/428 - (45%)	Gaps:	56/428 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 IYDARSREYALIN------RKLEAKDL--QKSIGWVPWV--PTTK--------ETNLLLANARRR 147
            :|.|.||...|.:      ||..|..:  |.....||.|  ||.:        |.|...|:...|
  Rat   198 LYQAASRSEYLTDYLENYGRKGSAPQVLTQAPPSRVPEVLSPTYRPSGRYTLWEKNKGQASGPSR 262

  Fly   148 LVRPNQTI-------GLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRH--DCG-SKSSHKCL 202
            ...|.:..       ||.||.|||.|||||.|:|.|.:|..|.||.:...:  |.| :.|:|..|
  Rat   263 STSPGRDTMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTAL 327

  Fly   203 VCEVSRLFQEFYSGS-RSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH----RHCVK 262
            :.|.::|.|..::.| ...:|.......|..:|....||.||||.||....||.||    |...:
  Rat   328 MEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVAAR 392

  Fly   263 AKAEHESKSNSSGSGSGTNS-----SNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTY 322
            .|...||..:......|...     ....|.         |..:|.|.|:|.:.|..|...||.:
  Rat   393 PKPSPESLDHLPDEEKGRQMWRKYLEREDSR---------IGDLFVGQLKSSLTCTDCGYCSTVF 448

  Fly   323 DPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPS 387
            |||||:||.:.:.    |....||:||:..:|:.:.|....|..|..|::.:...|:||::..|.
  Rat   449 DPFWDLSLPIAKR----GYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPK 509

  Fly   388 VVSFHLKRFEHSALIDRKISSFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHY 451
            ::..|||||..|.:...|:::|:.||: :.|:..|.||..|   ...::||||.||.||...|||
  Rat   510 ILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTN---HAVYNLYAVSNHSGTTMGGHY 571

  Fly   452 TAYVRHQ-KDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            |||.|.. ...|...:|..:|..|..||..|:.|||||
  Rat   572 TAYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDAYLLFY 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	0/1 (0%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	119/346 (34%)
Usp2	NP_446226.3	Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	1..213		5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..112
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..274		5/27 (19%)
		UCH	280..609	CDD:395355	117/344 (34%)
		Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	416..516		32/112 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910