Protein Alignment not and USP18

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_059110.2
• Gene: USP18 / 11274
• HGNCID: 12616
• Length: 372
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 81/385 - (21%)
• Similarity: 144/385 - (37%)
• Gaps: 76/385 - (19%)

  Fly   342 KETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALV----HTPLLSDYFMSDRHDCGS 402
            :::|:.....|.|....:...||.||.|:|.||.:|.::|..|    .|.:|....:..    |:
Human    32 EDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPR----GA 92

  Fly   403 KSSHKCLVCEVSRLFQEFYSGSRS---PLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH 464
            ....:.:..::..|.::.....:.   ||.|...|...     ::..:.|.||.:.::...:::.
Human    93 DEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKC-----NVPLFVQHDAAQLYLKLWNLIK 152

  Fly   465 R-----HCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNG 524
            .     |.|:.                                  :..::|..::..::|..|..
Human   153 DQITDVHLVER----------------------------------LQALYTIRVKDSLICVDCAM 183

  Fly   525 VSTTYDPFWDISLDLGETTTHGGVTP-KTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFS 588
            .|:.......:.|.|.:..:    .| |||.|.|..:.:...|.|.:|..|..|.......:...
Human   184 ESSRNSSMLTLPLSLFDVDS----KPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLK 244

  Fly   589 LRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNA-----YGDFRFSLYAVVN 648
            |..||..::.||.||.......|||...:.||...|.:..:..|:.:     ....::.|:||:.
Human   245 LTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIA 309

  Fly   649 HVGTIDTGHYTAYVRHQKD-TWVKCDDHVITMASLKQVLDSEG----------YLLFYHK 697
            |||..|:|||..|:|:..| .|...:|..|.:.|.:.:..:.|          |||.|.|
Human   310 HVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMK 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464
		Peptidase_C19D	365..696	CDD:239125	74/359 (21%)
USP18	NP_059110.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..45		2/12 (17%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	36..51		2/14 (14%)
		Mediates interaction with STAT2. /evidence=ECO:0000269|PubMed:28165510	51..112		15/64 (23%)
		UCH	55..367	CDD:425685	74/358 (21%)
		Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269|PubMed:28165510	303..312		4/8 (50%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	313..372		17/57 (30%)