DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP19

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_005264880.1	Gene:	USP19 / 10869	HGNCID:	12617	Length:	1423	Species:	Homo sapiens

Alignment Length:	731	Identity:	118/731 - (16%)
Similarity:	175/731 - (23%)	Gaps:	408/731 - (55%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHD--------------CGSKSSHKCLVCEV 206
            |..||:|||.|||||.::|:|.:|..|.|:|    ||              .|.:     |....
Human   600 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFF----HDRSFEAEINYNNPLGTGGR-----LAIGF 655

  Fly   207 SRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKS 271
            :.|.:..:.|:.......:|..::.:.|....||.|.||.||....||.||....:.:.:..:::
Human   656 AVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTET 720

  Fly   272 -NSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPF---------- 325
             :|.|......:..:...|.....:.|:| :|.|..:|.:||..|..||.|:|||
Human   721 VDSDGRPDEVVAEEAWQRHKMRNDSFIVD-LFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQK 784

  Fly   326 ----------------------------------------------------------------- 325

Human   785 QKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLP 849

  Fly   326 ----------------------------------------------------------------- 325

Human   850 SHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCT 914

  Fly   326 ----------------WDI---------------------------------------------- 328
                            |..
Human   915 RCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPP 979

  Fly   329 ----------------------SLDLGET------------------------------------ 335
                                  ||:.|::
Human   980 FQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVP 1044

  Fly   336 TTHG------------------------------------------------------------- 339
            :|.|
Human  1045 STSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLE 1109

  Fly   340 --GVTPK-----------------------------------------------TLIDCLERYTR 355
              |.||.                                               ||..||..:||
Human  1110 DKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTR 1174

  Fly   356 AEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDR-KISSFIQFPV-EFDM 418
            .|.|.......|..||.::|::||..|..||:|:...||||...:.|.| ||:..::||| ..|:
Human  1175 PEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDL 1239

  Fly   419 TPF-MSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDT--------WVKCDDHVITMAS 474
            :.| :.:|:.....  :.||||:||.|.:..|||||..|...|.        |...||..:|...
Human  1240 SKFCIGQKEEQLPS--YDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVD 1302

  Fly   475 LKQVLDSEGYLLFYHK 490
            ..||:....|:|||.:
Human  1303 ESQVVTRYAYVLFYRR 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	116/726 (16%)
USP19	XP_005264880.1	p23_like	120..202	CDD:107220
		p23_CS_SGT1_like	391..487	CDD:107223
		USP19_linker	478..600	CDD:293210	118/731 (16%)
		Peptidase_C19	574..>707	CDD:271592	35/115 (30%)
		Peptidase_C19	603..>789	CDD:271592	52/195 (27%)
		USP7_C2	803..>862	CDD:291217	0/58 (0%)
		zf-MYND	896..938	CDD:280009	1/41 (2%)
		Peptidase_C19R	<1160..1317	CDD:239139	55/158 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910