DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP39

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001243654.1	Gene:	USP39 / 10713	HGNCID:	20071	Length:	565	Species:	Homo sapiens

Alignment Length:	528	Identity:	115/528 - (21%)
Similarity:	192/528 - (36%)	Gaps:	141/528 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DARERKAIHCNCFE--------------CG---SYGIQLYACLHC-IYFGCRG--AHITSHLRSK 79
            |:.:|::.||...:              |.   |: |..||||.| .||..||  :|...|....
Human    96 DSEDRRSRHCPYLDTINRSVLDFDFEKLCSISLSH-INAYACLVCGKYFQGRGLKSHAYIHSVQF 159

  Fly    80 KHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVPWVPTTKETNLLLANA 144
            .|:|.|.|.  ||..|...|        .|.:|:..||      .|.:| ..||..:..:...:.
Human   160 SHHVFLNLH--TLKFYCLPD--------NYEIIDSSLE------DITYV-LKPTFTKQQIANLDK 207

  Fly   145 RRRLVR----PNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCE 205
            :.:|.|    .....|:.||.|:.|..:.|.::|||.:.|.|.:||:.:.:....|.....::..
Human   208 QAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFL 272

  Fly   206 VSRLFQEFYSGSRSPLSLHRLLHLIW---NHAKHLAGYE-----------------QQDAHEFFI 250
            :.:.|.|             |:..:|   |...|::.:|                 |.|..:|..
Human   273 LVQRFGE-------------LMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLS 324

  Fly   251 ATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQAC 315
            ..|:.||                |..| ||.....:          |:..:|.|.::
Human   325 WFLNALH----------------SALG-GTKKKKKT----------IVTDVFQGSMR-------- 354

  Fly   316 NGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSA------------------ 362
              :.|...|..|:..:..|...|.....:|:::....|...: |.:|
Human   355 --IFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLD-LPTAPLYKDEKEQLIIPQVPLF 416

  Fly   363 ---AKIKCST---CKSYQES-TKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPV-EFDMT 419
               ||....|   .|:|:|: .|:|.|..||..:.|.:|||..:.....|..:.:.||: ..|:.
Human   417 NILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLR 481

  Fly   420 PFMSEKKNA-YGDFRFSLYAVVNHVGTIDTGHYTAYV-RHQKDTWVKCDDHVITMASLKQVLDSE 482
            .::||:..| :.:..:.|.|.:.|.|....|.|..:| .|....|.:..|..:|....:.:..||
Human   482 EYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSE 546

  Fly   483 GYLLFYHK 490
            .|:..:.:
Human   547 AYIQIWKR 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	22/76 (29%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	78/378 (21%)
USP39	NP_001243654.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95
		Peptidase_C19M	106..553	CDD:239134	111/515 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910