DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp9y

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001316831.1	Gene:	Usp9y / 103694559	RGDID:	9087771	Length:	2552	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	120/567 - (21%)
Similarity:	191/567 - (33%)	Gaps:	195/567 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 ITSHLRS-----KKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVPWV 131
            :|..|.|     ||:::..:.....|......|||:.| |:.|...:|..|..:.|.    :|..
  Rat  1435 VTKELLSFQTPDKKYHIGCKAGGANLVKELIDDFIFPA-SKAYLQYSRSGEMPNKQT----IPVC 1494

  Fly   132 PTTKETN----LLLANA---RRRL----------------------------VRPNQTIGLRGLL 161
            .:....|    ||:|.|   .|.|                            |.|....|..||.
  Rat  1495 GSPATVNAGFELLVALAFGCVRNLKQIVNCLTEMFYIGTPVNTLAEWEYLPPVGPRPPKGFVGLK 1559

  Fly   162 NLGATCFMNCIVQALVHTPLL---------------SDYFMSDRHDCGSKSSHKCLVCEVSRLFQ 211
            |.||||:||.::|.|...|.:               .|.|..:|.|..:....:..|......|:
  Rat  1560 NAGATCYMNSVIQQLYMIPSIRNSILAIENIWNDTDDDTFKDERQDSENNIDPRDDVFGYPHQFE 1624

  Fly   212 E----FYSGSRSPLSLHRLLHL-------------------------IWNHAKHLAGYEQQDAHE 247
            :    ..:..|...::..|.||                         :|....:|.  ||.||.|
  Rat  1625 DKPTLNKAEDRKDYNIGVLKHLQITFGHLAASQLQYYVPRGFWQQFRLWGEPVNLR--EQHDALE 1687

  Fly   248 FFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVC 312
            ||.:.:|.|. ...||            .|..|                ::.::..|......:|
  Rat  1688 FFNSLVDSLD-EAFKA------------LGHPT----------------LLSKVLGGSFADQKIC 1723

  Fly   313 QACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQEST 377
            |.|.......:.|..:::|:   ..|     :.|:|.||:|.:.:.|..|....|..|....::.
  Rat  1724 QGCPHRYECEESFTTLNVDI---RNH-----QNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTV 1780

  Fly   378 KQFSLRTLPSVVSFHLKRFEHS-----ALIDRKISSFIQFPVEFDMTPFM--------------- 422
            |:..::.||||::..||||::.     |:   |.:.:.:||.|.||.|:.
  Rat  1781 KRLLIKKLPSVLAIQLKRFDYDWERECAI---KFNDYFEFPRELDMEPYTVAGATKLEGDGVHPQ 1842

  Fly   423 -------SEKKNAY-GDFRFSLYAVVNHVGTIDTGHYTAYV--RHQKDT----WVKCDDHVITMA 473
                   .:.:|.. |..::.|..|:.|.|..:.|||.:|:  |:.||.    |.|.||..:|..
  Rat  1843 TQLIKQNEQSENVVPGSTKYRLVGVLVHSGQANGGHYYSYIIQRNGKDNNRGRWFKFDDGDVTEC 1907

  Fly   474 SLK----------------QVLDS--------------EGYLLFYHK 490
            .:.                :|.|.              ..|:|||.:
  Rat  1908 KMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYER 1954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	9/35 (26%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	93/438 (21%)
Usp9y	NP_001316831.1	peptidase_C19C	1554..1957	CDD:239124	95/443 (21%)
Usp9y	NP_001316831.1	UCH	1556..1952	CDD:278850	92/437 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910