DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp24

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_002931653.2	Gene:	usp24 / 100497137	XenbaseID:	XB-GENE-6035156	Length:	2577	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	104/446 - (23%)
Similarity:	164/446 - (36%)	Gaps:	114/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 EYALINRKLEAKDLQKSIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCI 172
            |.:|.|.:|..|:| .|:...|....|||.:.|..      |......|..||.|.||||:||.:
Frog  1608 ESSLANLQLITKEL-LSMHHQPDPAVTKEFDYLPP------VDSRSNSGFVGLKNGGATCYMNAV 1665

  Fly   173 VQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRS---PLSLHRLLHLIWNHA 234
            .|.|...|.|.:..:|...|  :.:..:.:..:|..||.........   |.:..::..: ||
Frog  1666 FQQLYMQPGLPEALLSMEGD--TDNPDESVFYQVQSLFGHLMESKLQYYIPENFWKIFKM-WN-- 1725

  Fly   235 KHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIID 299
            |.|...|||||:|||.:.:|.:..:..|...|.                             |..
Frog  1726 KELYVREQQDAYEFFTSLIDQMDEYLKKMGREQ-----------------------------IFK 1761

  Fly   300 QIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAK 364
            ..|.|:.....:|:.|.......:.|  ::|:||.|:.      ::|...|:::.|.|.|..:..
Frog  1762 NTFQGIYSDQKICKDCPHRYEREEAF--MALNLGVTSC------QSLEISLDQFVRGEILEGSNA 1818

  Fly   365 IKCSTCKSYQESTKQFSLRTLPSVVSFHLKRF----EHSALIDRKISSFIQFPVEFDMTPFM--- 422
            ..|..||..:.:.|:..:::||||:..||.||    |....|  |....|:||...:|.|:.
Frog  1819 YYCEKCKDKRTTVKRTCIKSLPSVLVIHLMRFGFDWESGRSI--KYDEQIKFPWMLNMEPYTVAG 1881

  Fly   423 ----------------------SEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ----KDT 461
                                  |.:|.......:.|..|:.|.|....|||.::::.:    |..
Frog  1882 MARQDSSCEAGENGRHIDPGGGSPRKKVAPTENYELVGVIVHSGQAHAGHYYSFIKDRRGSGKGK 1946

  Fly   462 WVKCDDHVITMASLK---------------QVLDS------------EGYLLFYHK 490
            |.|.:|.|:....|.               :|.|.            ..|:|||.:
Frog  1947 WYKFNDTVVEEFDLNDETIEYECFGGEYRPKVYDQSNPYPDVRRRYWNAYMLFYQR 2002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	89/393 (23%)
usp24	XP_002931653.2	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	917..995	CDD:340585
		peptidase_C19C	1649..2005	CDD:239124	91/398 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910