DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp22

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001192175.2	Gene:	usp22 / 100379835	XenbaseID:	XB-GENE-6086060	Length:	572	Species:	Xenopus tropicalis

Alignment Length:	546	Identity:	277/546 - (50%)
Similarity:	348/546 - (63%)	Gaps:	73/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSETGCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYF 65
            ||..||.|..|:..|:.....|||...|......:.|:|||..|.|..||::..:|::||:|::|
Frog    50 MSPAGCSHVNSFKVENWKQNLRVIYQCFVWSGTPETRKRKAKSCICHMCGAHLNRLHSCLYCVFF 114

  Fly    66 GC-RGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVP 129
            || ...||..|.::|:||:|::|.:|.:||:.|:|:|||....:.|    |.|.:...|...:.|
Frog   115 GCFTKKHIHEHAKNKRHNLAIDLLYGGIYCFMCQDYIYDKDMEQVA----KEEQRKAWKLQAFSP 175

  Fly   130 -------------------WVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQA 175
                               |.||.:|..||..|.:||.:..|.|||||||:|||.||||||||||
Frog   176 ALVSPYQYAMTGVGEKYSTWEPTKRELELLQHNPKRRKITTNCTIGLRGLINLGNTCFMNCIVQA 240

  Fly   176 LVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGY 240
            |.|||||.|:|:||||.|..:|.:.|||||:|.||||||||.|||...:|||||:|.||:|||||
Frog   241 LTHTPLLRDFFLSDRHKCEMQSPNSCLVCEMSTLFQEFYSGHRSPHIPYRLLHLVWTHARHLAGY 305

  Fly   241 EQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGM 305
            ||||||||.||.||||||||             .|..:|..::|.:      .|||||||||||.
Frog   306 EQQDAHEFLIAALDVLHRHC-------------KGDDNGKKANNPN------HCNCIIDQIFTGG 351

  Fly   306 LQSDVVCQACNGVSTTYDPFWDISLDL-GETTTHGGVTP----------------KTLIDCLERY 353
            |||||.||.|:|||||.|||||||||| |.:|....::|                .||.|||.|:
Frog   352 LQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSDSAVVNGESHVSGTTTLTDCLRRF 416

  Fly   354 TRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDM 418
            ||.|||||:||||||.|.||||||||.:::.||.|..||||||||||.:.|||::::.||:|.||
Frog   417 TRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDM 481

  Fly   419 TPFMSEKKNA-------------YGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVKCDDHVI 470
            ||||:..|.:             :.|.::||:|||||.||:::||||:::|..||.|.||||.:|
Frog   482 TPFMASSKESRMNGQYQQPSDSLHNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAII 546

  Fly   471 TMASLKQVLDSEGYLLFYHKNVLEYE 496
            |.||:|.|||||||||||||..||||
Frog   547 TKASIKDVLDSEGYLLFYHKQFLEYE 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	24/57 (42%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	209/360 (58%)
usp22	NP_001192175.2	zf-UBP	95..155	CDD:366940	26/59 (44%)
usp22	NP_001192175.2	Peptidase_C19D	223..565	CDD:239125	209/360 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	403	1.000	Domainoid score	I713
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52664
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1244
OMA	1	1.010	-	-		QHG59954
OrthoDB	1	1.010	-	-		D200191at33208
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		oto103377
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110