DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP17L13

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001243784.1	Gene:	USP17L13 / 100287238	HGNCID:	44441	Length:	530	Species:	Homo sapiens

Alignment Length:	378	Identity:	112/378 - (29%)
Similarity:	180/378 - (47%)	Gaps:	68/378 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PTTKETNL-----LLANARRRLVRPNQTIGLR-------GLLNLGATCFMNCIVQALVHTPLLSD 184
            |.:.||.:     |:..||:...|....:..|       ||.|:|.||::|..:|.|.:||.|::
Human    42 PLSCETRVDLCDDLVPEARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLAN 106

  Fly   185 YFMSDRHDCGSKSSHK---CLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGY---EQQ 243
            |.:|..|   |::.|:   |::|.:.         :....:||...|:|.......||:   :|:
Human   107 YMLSREH---SQTCHRHKGCMLCTMQ---------AHITRALHNPGHVIQPSQALAAGFHRGKQE 159

  Fly   244 DAHEFFIATLDVLHRHCVKA--KAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGML 306
            |||||.:.|:|.:.:.|:..  :.:|.||..:                       :|.|||.|..
Human   160 DAHEFLMFTVDAMKKACLPGHKQVDHPSKDTT-----------------------LIHQIFGGYW 201

  Fly   307 QSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCK 371
            :|.:.|..|:|:|.|:||:.||:||:        ...:::...||:..:.|.|.......|..|.
Human   202 RSQIKCLHCHGISDTFDPYLDIALDI--------QAAQSVQQALEQLVKPEELNGENAYHCGVCL 258

  Fly   372 SYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSL 436
            ....::|..:|.|...|:...||||  |.:...||:..:|:|...||.|:||::..  |...:.|
Human   259 QRAPASKTLTLHTSAKVLILVLKRF--SDVTGNKIAKNVQYPECLDMQPYMSQQNT--GPLVYVL 319

  Fly   437 YAVVNHVG-TIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            |||:.|.| :...|||.:||:.|:..|.|.||..:|.||:..||..:.|:|||
Human   320 YAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTAASITSVLSQQAYVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	105/347 (30%)
USP17L13	NP_001243784.1	Peptidase_C19E	79..373	CDD:239126	104/341 (30%)
		UCH	80..372	CDD:278850	102/338 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..412
		HABP4_PAI-RBP1	<426..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910