DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32199 and CG34345

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	192/513 - (37%)
Similarity:	304/513 - (59%)	Gaps:	51/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIYSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLN 65
            :|||.|:.::.:|.|:|.|...:|:.||..:|.|:..::::.:||....|....::.:|||||||
  Fly    35 VIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLN 99

  Fly    66 AFPMLRRLNQDWPKWLRYIK-LAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAED 129
            :|.:|||.:|||||.:.|:| .......|:||...:...|..:|::.||.||.|||.|::|.:.|
  Fly   100 SFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLINRTPHANDMEEALMGMDRIEHFYDLKSSD 164

  Fly   130 LTKGVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTHPRGMIYAKVLGLKRKR 194
            :.:|::.|::|:|.::|.||:||.||.|.:::|..:..|||:||.|.|.|:..|..|....|||.
  Fly   165 MAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTKPKNNIAFKFYAPKRKE 229

  Fly   195 IYKKYAKALLKESLNSDKSKPTPTEKSEWNRLAKEVTREDNYDNVKKLIDEYLSGDEKIFQEVAA 259
            :.|.:..:.|:|.     |....|:      ..||::::.|...|.                  .
  Fly   230 LEKMFVISRLQEG-----SVENLTD------CLKELSQDPNNSLVH------------------L 265

  Fly   260 RLKRKPTKLERGCRGEWPKKSSPELICRYNRDTSAFLKLAPLKLEFLSVQPMILLYHDVLYENEF 324
            |.::.||.:|:||:|::|  ..|:|:||||..|:.|:::||||.|.:|..|:|.|||||:|::|.
  Fly   266 RPRKSPTMIEQGCQGKFP--PGPQLVCRYNSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEI 328

  Fly   325 KSMRDIAMYNGSMIDGWTYVDFDKKGNPKQQDRV-----VKMIAFQGTTAPFTLSINRRMADMSG 384
            ..:.::.  ...||.|.|       .|....|||     :|:....|.....|| :| ||||:||
  Fly   329 AQLTNVT--REEMILGTT-------TNYTTPDRVNRLFHIKVTDDDGGKLDKTL-VN-RMADISG 382

  Fly   385 LEMRDNMVLYLTNYGLGGHFGKHVDYVELAKRPPDFFADFGGDRIATALIYASDIPLGGTTVFTK 449
            |::.:...|...||||||:|.:|.||::: |..|:...:  |||:.|.|.|.:|:|:||||:|..
  Fly   383 LDVGNTTTLARINYGLGGYFQEHSDYMDI-KLYPELTEE--GDRLMTFLFYMTDVPVGGTTIFPG 444

  Fly   450 LKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVLGSRWIISKWIHERQQVFKKPC 507
            .::|:||||||||.|:||::.|:|:.||.|:|||.::||||::.|.:...:|:|||||
  Fly   445 AQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	47/129 (36%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	61/127 (48%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	47/129 (36%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	72/178 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461972
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D1438683at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910