DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32199 and P4HA1

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_000908.2	Gene:	P4HA1 / 5033	HGNCID:	8546	Length:	534	Species:	Homo sapiens

Alignment Length:	525	Identity:	172/525 - (32%)
Similarity:	264/525 - (50%)	Gaps:	37/525 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAF 67
            :.||:..|..|:..|:.|.|:|..|::..:.||:.||.:.:.|.|:|.|..::.|.:|.:|:|||
Human    21 FFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAF 85

  Fly    68 PMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTK 132
            .:::|||.:|.:....:...::...|..:.:|.:..|.|:|...|.|.:.|::..:||..:.::|
Human    86 KLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISK 150

  Fly   133 GVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTHPRGMIYAKVLGLKRKRIYK 197
            |.|.|.|..|.|||.||..||...|.:..:..:..|...|||...........||..|.    |.
Human   151 GNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLD----YL 211

  Fly   198 KYA--------KALL--KESLNSDKSKPTPTEKSEWNRLAKEVTREDNYDNVKKLIDEYLSGDEK 252
            .||        ||||  |:.|..|...    :::..|....|.......|..|...|:  ..|:|
Human   212 SYAVYQQGDLDKALLLTKKLLELDPEH----QRANGNLKYFEYIMAKEKDVNKSASDD--QSDQK 270

  Fly   253 IFQE---VAARLKRKPTKLERGCRGEWPK---KSSPELICRY---NRDTSAFLKLAPLKLEFLSV 308
            ...:   ||.....:..|.|..||||..|   :...:|.|||   ||:.. |: |||.|.|....
Human   271 TTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPK-FI-LAPAKQEDEWD 333

  Fly   309 QPMILLYHDVLYENEFKSMRDIAMYNGSMIDGWTYVDFDKKGNPKQQDRVVKMIAFQGTTAPFTL 373
            :|.|:.:||::.:.|.:.::|:|.   ..:...|..|.:.......|.||.|.....|...|...
Human   334 KPRIIRFHDIISDAEIEIVKDLAK---PRLSRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVS 395

  Fly   374 SINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELAKRPPDFFADFG-GDRIATALIYAS 437
            .||.|:.|::||::.....|.:.|||:||.:..|.|:..  |..||.|.:.| |:||||.|.|.|
Human   396 RINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFAR--KDEPDAFKELGTGNRIATWLFYMS 458

  Fly   438 DIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVLGSRWIISKWIHERQQV 502
            |:..||.|||.::..:|.||||:|:.|:||..:||.|..|.|:.|||::|::|:.:||:|||.|.
Human   459 DVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQE 523

  Fly   503 FKKPC 507
            |::||
Human   524 FRRPC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	38/128 (30%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	55/128 (43%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	25/86 (29%)
		TPR	205..238		12/36 (33%)
		P4Hc	345..518	CDD:214780	65/177 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870