DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32199 and p4ha2

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	541	Identity:	152/541 - (28%)
Similarity:	241/541 - (44%)	Gaps:	72/541 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAFPM 69
            ||...|..|:..|..|..:|..|::|.:.:|..||.:...:..::..:..:.|.|:.:|:||:.:
Frog    25 TSTGQMTDLIFRERDLLQSLKEYIREEEERLSKIKRWASEVDELSSRSTADPEGYLGHPVNAYKL 89

  Fly    70 LRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTKGV 134
            ::|.|.||......:....|...|.....|.:..|.::|...|.:.:.||:..:.|..:.:.||.
Frog    90 VKRFNTDWSSLENLVLQDSAKGFIANFTFQREYFPTEEDETGAARALMRIQDTYKLDPDVIAKGK 154

  Fly   135 LMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTHPRGMIYAKVLGLKRKRIYKKY 199
            |.|....|.|:|.|...:|...|:...:..:..|.:.||:........:..||..|.    |..|
Frog   155 LPGTNYISSLSADDSFGMGKIAYHDGDYYHTVLWMQQALKQMDEGEDAVVNKVDVLD----YLSY 215

  Fly   200 AKALLKESLNSDKSKPTPTEKSEWNRLAKEVTREDNYDNVKKLIDEYLSGDEKIFQEVAARLK-- 262
            ....|.:       .|...|.:: ..||.:...:...:|:|..        ||:.::..|.||
Frog   216 TVFQLGD-------VPRALELTK-RLLALDPNHDRAVNNLKYF--------EKMQEKQKAELKQN 264

  Fly   263 ---------RKPTKLERG-------------CRGEWPK---KSSPELICRY-NRDTSAFLKLAPL 301
                     |:|....|.             ||||..|   :....|.||| |.:.|.:|.|:|:
Frog   265 ESTNTESATRQPGVYSRPLDYLPERDVYEALCRGEGVKMNPRRQRRLFCRYHNGNRSPYLILSPV 329

  Fly   302 KLEFLSVQPMILLYHDVLYENEFKSMRDIA---MYNGSMIDGWTYVDFDKKGNPK------QQDR 357
            |:|.....|.|:.|.:.|.:.|...::::|   :...::.|            ||      ...|
Frog   330 KVEDEWDSPRIVRYLNALSDEEIAKIKELAKPKLARATVRD------------PKTGVLSVANYR 382

  Fly   358 VVKMIAFQGTTAPFTLSINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELAKRPPDFFA 422
            |.|....:....|....:|.||..::||.:....:|.:.|||:||.:..|.|:..  |..||.|.
Frog   383 VSKSAWLEENDDPVIARVNLRMQAITGLTVDTAELLQVANYGMGGQYEPHFDFSR--KDEPDVFK 445

  Fly   423 DFG-GDRIATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVL 486
            ..| |:|:||.|.|.||:..||.|||.....|:.||||:|:.|:||..:||.|..|.|:.|||::
Frog   446 RLGTGNRVATFLNYMSDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAACPVLV 510

  Fly   487 GSRWIISKWIHERQQVFKKPC 507
            ||:|:.:||.|||.|.|.:||
Frog   511 GSKWVSNKWFHERGQEFLRPC 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	31/128 (24%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	54/128 (42%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	20/85 (24%)
		TPR repeat	166..201	CDD:276809	7/34 (21%)
		TPR repeat	206..236	CDD:276809	9/41 (22%)
		P4Hc	348..521	CDD:214780	62/186 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010