DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32199 and CG15539

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	152/526 - (28%)
Similarity:	265/526 - (50%)	Gaps:	69/526 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAF 67
            |:.|:..|.||::.|..|...|..:...:|.::|.::.|      :.:|..:.::....:|:..|
  Fly    30 YAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYY------LEMTDYDREKNLAEDPIKHF 88

  Fly    68 PMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTK 132
            .:.|||:.|:..|:.:::.......:|::.......|...|::.|::|:..|:..::|...::.|
  Fly    89 RITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAPEMPTLKDVEEAIRGLRLIQWTYSLPTAEMAK 153

  Fly   133 GVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTHPRGM--IYAKVLGLKRKRI 195
            |||.....|:.|....|:.:..:..|...|..:..|..:.|:::.....:  ||:: ||:.....
  Fly   154 GVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEEIEYIYSQ-LGMPLVDF 217

  Fly   196 YKKYAKALLKESLNSDKSKPTPTEKSEWNRLAKEVTREDNYDNVKKLIDEYLSGDEKI-FQEVAA 259
            |:.:.:  :::.|.|                        .|..:.:|.....:..||: .|...:
  Fly   218 YELFVE--IQDELGS------------------------RYLAMSELQLAIKNWPEKVSLQRALS 256

  Fly   260 RLK------RKPTKLERGCRGEWPKKSSPE------LICRYNRDTSAFLKLAPLKLEFLSVQPMI 312
            |||      ::|.:.:...:..:.|..|.|      |.|.|...:|.||:|||||:|.||:.|.:
  Fly   257 RLKMNIRIGKEPAEKKNKSKRVYKKCCSSECRPTAKLYCLYKTTSSYFLRLAPLKMELLSLDPYM 321

  Fly   313 LLYHDVLYENEFKSMRDIAMYNGSMIDGWTYVDFDKKGN-PKQQDRVVKMIAFQGTTAPFTLSIN 376
            :|:|||:.:.:..|:|::.  .|.:.   ..|...|.|| .:..||..|     ||......::.
  Fly   322 VLFHDVVSDKDIVSIRNLT--KGKLA---RTVTVSKDGNYTEDPDRTTK-----GTWLVENNALI 376

  Fly   377 RRMA----DMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELAKRPPDFFADFGGDRIATALIYAS 437
            :|::    ||:..::.|.....:.|||:||.:|.|.|::|      |...|...||||||:.|.|
  Fly   377 QRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLE------DAELDNFSDRIATAVFYLS 435

  Fly   438 DIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVLGSRWIISKWIHERQQV 502
            |:|.||.|:|.||.::|.|||||||:|:||:|.|:.|..|.||.||.|:||||:::|||:||:|:
  Fly   436 DVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQI 500

  Fly   503 FKKPCL 508
            |::|||
  Fly   501 FRRPCL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	27/128 (21%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	57/131 (44%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	27/128 (21%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	68/180 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461988
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900