DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32199 and P4ha2

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	153/530 - (28%)
Similarity:	252/530 - (47%)	Gaps:	48/530 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAF 67
            :.||:..|..|:..|:.|..:|..|:...::||..||.:...::.:|..:..:.|.|:::|:||:
  Rat    23 FFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNAY 87

  Fly    68 PMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTK 132
            .:::|||.|||.....:....|:..:..:.||.:..|.|:|...|.:.:.|::..:.|..:.:::
  Rat    88 KLVKRLNTDWPALGDLVLQDAAAGFVANLSVQRQFFPTDEDESGAARALMRLQDTYKLDPDMISR 152

  Fly   133 GVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTHPRGMIYAKVLGLKRKRIYK 197
            |.|.|.|..:.|:..||..:|...||:..:..:..|....|:...........|.|.|.    |.
  Rat   153 GELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATVTKSLVLD----YL 213

  Fly   198 KY----------AKALLKESLNSDKSKPTPTEKSEWN-RLAKEVTREDNYDNVKKLIDEYLSGDE 251
            .|          |..|.:..|:.|.|.    |::..| |..:.:..|:...::....|..|:..|
  Rat   214 SYAVFQLGDLHRAVELTRRLLSLDPSH----ERAGGNLRYFERLLEEERGKSLSNQTDAGLASQE 274

  Fly   252 KIFQEVAARLKRKPTKLERGCRGEWPK---KSSPELICRYNRDTSA-FLKLAPLKLEFLSVQPMI 312
            .:::.....|..:.. .|..||||..|   :....|.|||:..... .|.:||.|.|.....|.|
  Rat   275 NLYERPVDYLPERDV-YESLCRGEGIKMTPRRQKRLFCRYHHGNRVPQLLIAPFKEEDEWDSPHI 338

  Fly   313 LLYHDVLYENEFKSMRDIA---MYNGSMIDGWTYVDFDKKGNPK------QQDRVVKMIAFQGTT 368
            :.|:||:.:.|.:.:::||   :...::.|            ||      ...||.|....:...
  Rat   339 VRYYDVMSDEEIERIKEIAKPKLARATVRD------------PKTGVLTVASYRVSKSSWLEEDD 391

  Fly   369 APFTLSINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELAKRPPDFFADFG-GDRIATA 432
            .|....:||||..::||.::...:|.:.|||:||.:..|.|:....:|  |.|...| |:|:||.
  Rat   392 DPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDER--DAFKRLGTGNRVATF 454

  Fly   433 LIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVLGSRWIISKWIH 497
            |.|.||:..||.|||..|..|:.||||:|:.|:||..:||.|..|.|:.|||::|.:|:.:||.|
  Rat   455 LNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFH 519

  Fly   498 ERQQVFKKPC 507
            ||.|.|.:||
  Rat   520 ERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	33/128 (26%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	54/128 (42%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	22/76 (29%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	63/186 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920