DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32199 and PH4alphaSG1

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	154/557 - (27%)
Similarity:	255/557 - (45%)	Gaps:	103/557 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEK-------EEYV 60
            |.:::..:.:||::|..:....|.|::..|.:       |::|||. |..::|:       |||.
  Fly    20 YYSAISELERLLDVEAFIVEKFDEYLERAQQE-------QENLKRF-LDQIDEQQNDRGDLEEYF 76

  Fly    61 SNPLNAFPMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSA--------PIDDDLKVALKGMT 117
            .||:|||..::||..||.  .........|...:..:..|..:        |..:||..|.:.:.
  Fly    77 GNPINAFITIKRLVHDWK--FNVFDPVFDSSNFETYKNNLSDSLEKINFKGPTQEDLHGATRALL 139

  Fly   118 RIEKFHNLHAEDLTKGVL-MGKK--LNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMA-LRVHTH 178
            |::..:.|:.:.|..||| .|:|  |.:.|:|.||..||.......::|..:.|...| .|:|..
  Fly   140 RLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLLEARKRLHGK 204

  Fly   179 PRGMIYAKVLGLKRKRIYKKYAKAL-------LKESLNSD--KSKPTPTEKSEWNRLAKE--VTR 232
            |.|.|...|..::   |.:..:.|.       |...||::  ..||...|..: |::..|  :.|
  Fly   205 PLGFISPNVSDVE---ILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALK-NKILYEGQLAR 265

  Fly   233 EDNYDNVKKLIDEYLSGDEKIFQEVAARLKRKPTKL-ERGCRGEWPK--KSSPELICRYNRDTSA 294
            |.::...|::          ...::|.:.:::..|| .:.||||..:  :....|.|........
  Fly   266 ERSFAPRKQV----------ELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLRCWLYHQGVP 320

  Fly   295 FLKLAPLKLEFLSVQPMILLYHDVLYENEFKSMRDIAMYNGSMIDGWTYVDFDKKGNPKQ----- 354
            :.:|:|.|:|.|:|.|.:...|:||:::|.    |..|.:|             |||.::
  Fly   321 YYRLSPFKIEQLNVDPYVAYVHEVLWDSEI----DTIMEHG-------------KGNMERSKVGQ 368

  Fly   355 -QDRVVKMIAFQGTT------APFTLSINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVE 412
             ::.....:.....|      .|:...|.:|:.|::||.......|.|.|||:||.:..|.|:||
  Fly   369 SENSTTSEVRISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVE 433

  Fly   413 LAKRPPDFFADFG-------GDRIATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHA 470
                      |.|       |:|:.|||.|.:|:.|||.|.|..|::||.|.|||.|||:||:.:
  Fly   434 ----------DDGQSVFSWKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSS 488

  Fly   471 GEPDPLTEHSVCPVVLGSRWIISKWIHERQQVFKKPC 507
            ...|..|:|:.|||:.||:||.::|.|...|.|::||
  Fly   489 THKDFRTKHAGCPVLQGSKWICNEWFHVGAQEFRRPC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	34/143 (24%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	54/134 (40%)
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	34/143 (24%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	62/194 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462010
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900