DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32199 and P4ha3

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_006508007.1	Gene:	P4ha3 / 320452	MGIID:	2444049	Length:	551	Species:	Mus musculus

Alignment Length:	558	Identity:	141/558 - (25%)
Similarity:	250/558 - (44%)	Gaps:	97/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TSVMSMMKLLEMEESLKTNLDIYVQEMQSKL-DLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAFP 68
            :::.|:.:.|..|..|...|..|::..:::| ||.:.|..     .|:..|:.:..|.|||.||.
Mouse    30 SALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFYDK-----VLSLHEDLKIPVVNPLLAFT 89

  Fly    69 MLRRLNQDWPKWLRYIKLAIASKKIKE-MEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTK 132
            :::||..||...:..::.....:.:|: .|...:..|..:||:.|.:.:.|::..:.|:.:.|.:
Mouse    90 LIKRLQSDWRNVVHSLEATENIRALKDGYEKVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLAR 154

  Fly   133 GV---LMGKKLNS--------HLTAPDCVAL----------------GDYYYNQTQFSGSTHWYR 170
            ||   :.|..:..        .|||.||..:                ||||:       :..|..
Mouse   155 GVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKPSCGSRSLQVAYDTGDYYH-------AIPWLE 212

  Fly   171 MALRVHTHPRGMIYAKVLGLKRKRIYKKYAKALLKE-------------------SLNSDKSKPT 216
            .|:.:.....|.             :|...:|.|::                   ||:.:....:
Mouse   213 EAVSLFRRAHGE-------------WKTEDEASLEDALDYLAFACFQVGNVSCALSLSREFLVYS 264

  Fly   217 PTEKSEWNRLAKEVTREDNYDNVKKLIDEYLSGDEKIFQEVAARLKRKPTKLERGCR--GEWPKK 279
            |..|    |:|:.|.:   |:.:.......::.:..|.:.....|:.:.| .|..|:  |..|..
Mouse   265 PDNK----RMARNVLK---YERLLAENGHQMAAETAIQRPNVPHLQTRDT-YEGLCQTLGSQPTH 321

  Fly   280 -SSPELICRYNRDTSAFLKLAPLKLEFLSVQPMILLYHDVLYENEFKSMRDIAMYNGSMIDGWTY 343
             ..|.|.|.|..::|.:|.|.|.:.|.:.::|:|.||||.:.:.|.:.:|::|       :.|..
Mouse   322 YQIPSLYCSYETNSSPYLLLQPARKEVVHLRPLIALYHDFVSDEEAQKIRELA-------EPWLQ 379

  Fly   344 VDFDKKGNPKQQ--DRVVKMIAFQGTTAPFTLSINRRMADMSGLEMRDNMVLYL--TNYGLGGHF 404
            ......|..:.|  .|:.|....:.|..|..::::.|:|.::||:::.....||  .|||:|||:
Mouse   380 RSVVASGEKQLQVEYRISKSAWLKDTVDPMLVTLDHRIAALTGLDIQPPYAEYLQVVNYGIGGHY 444

  Fly   405 GKHVDYVELAKRPPDFFADFGGDRIATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNH 469
            ..|.|:......|  .:....|:|:||.:||.|.:..||.|.|.....:|...|.:||.|:||:.
Mouse   445 EPHFDHATSPSSP--LYRMKSGNRVATFMIYLSSVEAGGATAFIYGNFSVPVVKNAALFWWNLHR 507

  Fly   470 AGEPDPLTEHSVCPVVLGSRWIISKWIHERQQVFKKPC 507
            :||.|..|.|:.|||::|.:|:.:|||||..|.|::||
Mouse   508 SGEGDGDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPC 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	33/133 (25%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	46/129 (36%)
P4ha3	XP_006508007.1	P4Ha_N	31..157	CDD:369820	32/130 (25%)
P4ha3	XP_006508007.1	P4Hc	363..535	CDD:214780	55/180 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839331
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740