Protein Alignment CG32199 and P4HA3

DIOPT Version :10

• Sequence 1: NP_730347.1
• Gene: CG32199 / 40028
• FlyBaseID: FBgn0052199
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 137/562 - (24%)
• Similarity: 227/562 - (40%)
• Gaps: 144/562 - (25%)

  Fly     5 TSVMSMMKLLEMEESLKTNLDIYVQEMQSKL-DLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAFP 68
            :::.|:.:.|..|..|...|..|::..:::| ||.:.|..     .|:..|:....|:|||.||.
Human    32 SALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDK-----VLSLHEDSTTPVANPLLAFT 91

  Fly    69 MLRRLNQDWPKWLRYIKLAIASKKIKEM----EVQLKSAPIDDDLKVALKGMTRIEKFHNLHAED 129
            :::||..||...:..::   ||:.|:.:    |...:..|..:||:.|.:.:.|::..:.|:.:.
Human    92 LIKRLQSDWRNVVHSLE---ASENIRALKDGYEKVEQDLPAFEDLEGAARALMRLQDVYMLNVKG 153

  Fly   130 LTKGVLM------------GKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTHPRGM 182
            |.:||..            .|:|.| ||..||..:|...|:...:..:..|...|:.:.   ||.
Human   154 LARGVFQRVTGSAITDLYSPKRLFS-LTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSLF---RGS 214

  Fly   183 IYAKVLGLKRKRIYKKYAKALLKESLNSDKSKPTPTEKSEWNRLAKEVTREDNYDNVKKLIDEYL 247
             |.:         :|...:|.|:::|               :.||....|..|......|..|:|
Human   215 -YGE---------WKTEDEASLEDAL---------------DHLAFAYFRAGNVSCALSLSREFL 254

  Fly   248 --SGDEKIFQEVAARLKRKPTKLER------------------------------G-CR--GEWP 277
              |.|.|       |:.|...|.||                              | |:  |..|
Human   255 LYSPDNK-------RMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQP 312

  Fly   278 K-KSSPELICRYNRDTSAFLKLAPLKLEFLSVQPMILLYHDVLYENEFKSMRDIAMYNGSMIDGW 341
            . ...|.|.|.|..:::|:|.|.|::.|.:.::|.|.||||.:.::|.:.:|::|       :.|
Human   313 TLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELA-------EPW 370

  Fly   342 TYVDFDKKGNPKQQ--DRVVKMIAFQGTTAPFTLSINRRMADMSGLEMRDNMVLYL--TNYGLGG 402
            ........|..:.|  .|:.|....:.|..|..:::|.|:|.::||::|.....||  .|||:||
Human   371 LQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGG 435

  Fly   403 HFGKHVDYVELAKRPPDFFADFGGDRIATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNL 467
            |:..|.|:......|  .:....|:|:||.:||.|.:..||.|.|....::|
Human   436 HYEPHFDHATSPSSP--LYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSV------------- 485

  Fly   468 NHAGEPDPLTEH---SVCP-VVLG----------SRWIISKW 495
                   |:..|   ..|. ||.|          |.|.||.|
Human   486 -------PVVRHCFGGTCTGVVKGTVTHFMLAVLSWWEISGW 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..137	CDD:462433	35/147 (24%)
		P4Hc	<369..497	CDD:214780	41/143 (29%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433	29/109 (27%)
		BepA	<188..289	CDD:443813	26/135 (19%)
		P4Hc	356..>478	CDD:214780	37/130 (28%)