DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32199 and p4ha1

DIOPT Version :9

Sequence 1:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	549	Identity:	173/549 - (31%)
Similarity:	260/549 - (47%)	Gaps:	92/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAF 67
            :.||:..|:.||..|:.|.|:|..|::..:.||..||.:.|.|..:|.|..::.|.|:.:|:|||
Frog    20 FFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTATKDPEGYLGHPVNAF 84

  Fly    68 PMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTK 132
            .:::|||.:|.|....|...|:...|..:.:|.:..|.|:|...|.|.:.|::..:||..:.::|
Frog    85 KLMKRLNTEWVKLENLILKDISDGFISNLTIQRQYFPNDEDQTGAAKALLRLQDTYNLDTDTISK 149

  Fly   133 GVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTHPRGMIYAKVLGLKRKRIYK 197
            |.|.|.|..:.|||.||..||...|....:..:..|...||............||:.|.    |.
Frog   150 GNLPGVKHKTSLTAEDCFDLGKTAYTDADYYHTELWMEQALSQLDAGEESSLDKVMVLD----YL 210

  Fly   198 KYA--------KA--LLKESL-------------------NSDKSKPTPTEKSEWNRLAKEVTRE 233
            .||        ||  |.|.||                   .|:||..:|:|.:|..      ||:
Frog   211 SYAVYQQGDLDKALTLTKRSLELDPEHQRGNGNLRHIMSKESNKSSSSPSEGAELR------TRK 269

  Fly   234 DN-YDNVKKLIDEYLSGDEKIFQEVAARLKRKPTKLERGCRGEWPKKSS---PELICRY-NRDTS 293
            .. .|:::|                        .|.|:.||||..|.:|   ..|.||| :....
Frog   270 GRPKDHLEK------------------------EKYEKLCRGEGVKMTSRRQKRLFCRYFDGKKD 310

  Fly   294 AFLKLAPLKLEFLSVQPMILLYHDVLYENEFKSMRDIA---MYNGSMIDGWTYVDFDKKGNP--- 352
            ..|.|:|.|.|....:|.|:.|||::.:.|...::::|   :...::            .||
Frog   311 PLLILSPTKQEDEWDKPRIVRYHDIISDEEISKVKELAKPRLRRATI------------SNPITG 363

  Fly   353 ---KQQDRVVKMIAFQGTTAPFTLSINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELA 414
               ..|.|:.|.....|...|....:|||:..::||:|.....|.:.|||:||.:..|.|:  |.
Frog   364 VLETAQYRITKSAWLSGYEDPVVARLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDF--LR 426

  Fly   415 KRPPDFFADFG-GDRIATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTE 478
            |..||.|...| |:|:||.|.|.||:..||.|||.::..||.||||:|:.|:||..:||.|..|.
Frog   427 KYEPDAFKKLGTGNRVATWLFYMSDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTR 491

  Fly   479 HSVCPVVLGSRWIISKWIHERQQVFKKPC 507
            |:.|||::|::|:.:||||||.|.|::||
Frog   492 HAACPVLVGNKWVSNKWIHERGQEFRRPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	42/128 (33%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	56/128 (44%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	29/86 (34%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	64/186 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110