DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and P4ha1

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	127/534 - (23%)
Similarity:	234/534 - (43%)	Gaps:	120/534 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPINAFS 81
            ::||.::..|:..|:..:|::|.|.....:|::.::.:.:.:|.....:.:|.|.:||:|:|||.
  Rat    22 FTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFK 86

  Fly    82 LVRRTHQDLPKWHNYSQQIV-GMEELFALEEIIAK--VPDKKDMAYSLGEMHRIEQIYDLEAIEL 143
            |::|.:.:   |......|: .|.:.|.....|.:  .|:.:|...:...:.|::..|:|:...:
  Rat    87 LMKRLNTE---WSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTI 148

  Fly   144 ARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPEGNAEIINSILGDPKVNL 208
            ::|.:.|.::....:..||..||:..:...||....:|...|:....||....::.:    .|..
  Rat   149 SKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKV----SVLD 209

  Fly   209 YTLYA--------KSMLIF-GMIKSNPSMTIAEAKKISYEAL-------NKASLADIKSLLNELL 257
            |..||        |::|:. .:::.:|....|....:.:|.:       ||::..|
  Rat   210 YLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGD--------- 265

  Fly   258 SQTDDEIVYEMNVNKTKP-------------SDYEIGCRGQFL-----RRRNHVCTYN--FTITE 302
             |:|         .||.|             ..||:.|||:.:     |::...|.|:  ....:
  Rat   266 -QSD---------QKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPK 320

  Fly   303 FLKLAPLKQEVLNWD-PYIVIYHDVLNDDEIDKLKN-----------HLNDTDAVEV-------- 347
            |: |||.|||. .|| |.|:.:||:::|.||:.:|:           |..:|..:..
  Rat   321 FI-LAPAKQED-EWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKS 383

  Fly   348 -------NPIEKRIFQRINELTRLSFEHSDQQIVSKNG------PR---THKHKKEYLK------ 390
                   :|:..||..||.:||.|....:::..|:..|      |.   ..|.:.:..:
  Rat   384 AWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGN 448

  Fly   391 --GTLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNTL-----DPRSEPLECPVLQGNKRV- 447
              .|.||::::|..|||.|||::..||:|:||:.:||:|..     |..:....||||.|||.|
  Rat   449 RIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVS 513

  Fly   448 ---ITQKGAYNGRP 458
               :.::|....||
  Rat   514 NKWLHERGQEFRRP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	30/131 (23%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	47/178 (26%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	22/89 (25%)
		TPR	205..238		7/36 (19%)
		P4Hc	345..518	CDD:214780	45/172 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920