DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and p4ha1a

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	545	Identity:	133/545 - (24%)
Similarity:	238/545 - (43%)	Gaps:	109/545 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NSGESEYVENNSVYSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFED 68
            :|..|::      ::||..:..||..|:..:|::|.|......|::.::.:.:.:|.....:.:|
Zfish    19 SSAHSDF------FTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQWAEKLDALTATAVQD 77

  Fly    69 REKYVGNPINAFSLVRRTHQDLPKWHNYSQQIV-GMEELFALEEIIAK--VPDKKDMAYSLGEMH 130
            .|.::|:|:|||.|::|.:.:   |......:: .|.:.|.....|.:  .|:.:|...:...:.
Zfish    78 PEGFLGHPVNAFKLMKRLNTE---WGEVEDLVLKDMSDGFISNLTIQRQYFPNDEDQNGAAKALL 139

  Fly   131 RIEQIYDLEAIELARGRIQGKQ----YDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPE 191
            |::..|.|:...::.|.:.|..    |....::.||..||:..:...||....:|...|:|...|
Zfish   140 RLQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYYHTELWMAQALKQLDE 204

  Fly   192 G---NAEIINSILGDPKVNLYTLYAKSMLIFGMIKSNPSMTIAEAKKISYEALNKASLADIKSLL 253
            |   :.||..::    ....|::|.:..|...:..:...:|:        |..::.:|.::|...
Zfish   205 GEESSVEIATAL----DYLSYSVYQQGELERALEYTKRLLTV--------EPEHQRALGNLKYFD 257

  Fly   254 NELLSQ--------TDDEIVYEMNVNKTKPS------DYEIGCRGQFL----RRRNHV-CTY-NF 298
            .:|..|        |.:|...|...:..|..      .||..|||:.|    ||:.|: |.| |.
Zfish   258 YQLAKQKKAEKEQSTKEESKKEQETSDGKKEYLPEKRKYEKLCRGEGLKMTPRRQKHLFCRYFNG 322

  Fly   299 TITEFLKLAPLKQEVLNWD-PYIVIYHDVLNDDEIDKLK-------------NHLNDTDAVEV-- 347
            ....|..:.|:|||. .|| |.|:.||:::.:.||:|:|             |.:  |..:|.
Zfish   323 NRHPFYTIGPVKQED-EWDRPRIIRYHEIITEQEIEKIKELSKPRLRRATISNPI--TGVLETAH 384

  Fly   348 -------------NPIEKRIFQRINELTRLSFEHSDQQIVSKNG------PR---THKHKKEYLK 390
                         :|:..||.|||.::|.|:.:.:::..|:..|      |.   ..|.:.:..|
Zfish   385 YRISKSAWLAAYEHPVVDRINQRIEDITGLNVKTAEELQVANYGVGGQYEPHFDFGRKDEPDAFK 449

  Fly   391 --------GTLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNTL-----DPRSEPLECPVLQ 442
                    .|.||::::|..|||.|||::..:|.|.||:.:||:|..     |..:....||||.
Zfish   450 ELGTGNRIATWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSGEGDYSTRHAACPVLV 514

  Fly   443 GNKRV----ITQKGAYNGRPMQYKK 463
            |||.|    |.::|....||...|:
Zfish   515 GNKWVSNKWIHERGQEFRRPCGLKE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	29/131 (22%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	48/180 (27%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	29/131 (22%)
		TPR repeat	172..207	CDD:276809	11/34 (32%)
		TPR repeat	212..242	CDD:276809	4/33 (12%)
		Fis1	218..262	CDD:304536	8/51 (16%)
		P4Hc	352..525	CDD:214780	46/174 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850