DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and P4HTM

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	459	Identity:	93/459 - (20%)
Similarity:	144/459 - (31%)	Gaps:	174/459 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 HNYSQQIVGMEELF----ALEEIIAKVP-----DKKDMAYSLGEMHRIE--QIYDLEAIELARGR 147
            |....|:|...:.|    :|:.::.::|     ::..:...|.:|..::  ||...|..|.|...
Human   121 HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMST 185

  Fly   148 IQGKQYD-FR--PSIRDCVALGEHKFKREDYQRASM---WFRVAIKHEPEGNAEIINSILGDPKV 206
            :|..|.| ||  ...||     .|...||...:..:   |:..     ||...|:..:|..||..
Human   186 MQVSQLDLFRLLDQNRD-----GHLQLREVLAQTRLGNGWWMT-----PESIQEMYAAIKADPDG 240

  Fly   207 NLYTLYAKSMLIFGMIKSNPSMTIAEAKKISYEALNKASLADIKSLLNELLSQTDDEIVYEMNVN 271
            :            |:              :|.:..:...|.|....               |..:
Human   241 D------------GV--------------LSLQEFSNMDLRDFHKY---------------MRSH 264

  Fly   272 KTKPSDYEIGCRGQFLRRRNHVCTYNFTITEFLKLAPLKQEVL---NWDPYIVIYHDVLNDDEID 333
            |.:.|        :.:|..:|...|.......:..| ::|.||   ...|.||...:.|......
Human   265 KAESS--------ELVRNSHHTWLYQGEGAHHIMRA-IRQRVLRLTRLSPEIVELSEPLQVVRYG 320

  Fly   334 KLKNHLNDTDAVEVNPIEKRIFQRINELTRL------SFEHSDQQIVSKN--------------- 377
            :..::....|:..|.|      :.|...|:|      .||.|.:| ||.|
Human   321 EGGHYHAHVDSGPVYP------ETICSHTKLVANESVPFETSCRQ-VSPNWGLPSILRPGTPMTQ 378

  Fly   378 ------------GPRTH--------KHKK---------EYLKGTLLFFLNNVELGGAMVFP---- 409
                        ||..|        :|.:         .|...|:||:||||..||..|||
Human   379 AQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVTGGGETVFPVADN 443

  Fly   410 -----------------------KLKISVFPQKGSCLFWHNTL----------DPRSEPLECPVL 441
                                   |..:.|.||:|:.:||:|.|          |..|....|.|.
Human   444 RTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVT 508

  Fly   442 QGNK 445
            :|.|
Human   509 RGTK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	13/64 (20%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	46/211 (22%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:290234	17/95 (18%)
		EFh	194..252	CDD:238008	16/93 (17%)
		P4Hc	246..519	CDD:214780	61/298 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740