Protein Alignment CG18231 and P4HA1

DIOPT Version :9

• Sequence 1: NP_649045.2
• Gene: CG18231 / 40026
• FlyBaseID: FBgn0036796
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 128/542 - (23%)
• Similarity: 230/542 - (42%)
• Gaps: 136/542 - (25%)

  Fly    17 YSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPINAFS 81
            ::||.::..|:..|:..:|::|.|.....:|::.::.:.:.:|.....:.:|.|.:||:|:|||.
Human    22 FTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFK 86

  Fly    82 LVRRTHQDLPKWHNYSQQIV-GMEELFALEEIIAK--VPDKKDMAYSLGEMHRIEQIYDLEAIEL 143
            |::|.:.:   |......:: .|.:.|.....|.:  .|:.:|...:...:.|::..|:|:...:
Human    87 LMKRLNTE---WSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTI 148

  Fly   144 ARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPEGNAEIINSILGDPKVNL 208
            ::|.:.|.::....:..||..||:..:...||....:|...|::...||....|:.:
Human   149 SKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKV-------- 205

  Fly   209 YTLYAKSMLIFGMIKSNPSMTIAEAKKISYEALNKASLADIKSLLNELLSQTDDE---------- 263
                  |:|.:                :||....:..| |...||.:.|.:.|.|
Human   206 ------SVLDY----------------LSYAVYQQGDL-DKALLLTKKLLELDPEHQRANGNLKY 247

  Fly   264 ----IVYEMNVNKTKPSD-----------------------YEIGCRGQFL-----RRRNHVCTY 296
                :..|.:|||:...|                       ||:.|||:.:     |::...|.|
Human   248 FEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRY 312

  Fly   297 N--FTITEFLKLAPLKQEVLNWD-PYIVIYHDVLNDDEIDKLKN-----------HLNDTDAVEV 347
            :  ....:|: |||.|||. .|| |.|:.:||:::|.||:.:|:           |..:|..:..
Human   313 HDGNRNPKFI-LAPAKQED-EWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTT 375

  Fly   348 ---------------NPIEKRIFQRINELTRLSFEHSDQQIVSKNG------PR---THKHKKEY 388
                           ||:..||..||.:||.|....:::..|:..|      |.   ..|.:.:.
Human   376 AQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDA 440

  Fly   389 LK--------GTLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNTL-----DPRSEPLECPV 440
            .|        .|.||::::|..|||.|||::..||:|:||:.:||:|..     |..:....|||
Human   441 FKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPV 505

  Fly   441 LQGNKRV----ITQKGAYNGRP 458
            |.|||.|    :.::|....||
Human   506 LVGNKWVSNKWLHERGQEFRRP 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	29/131 (22%)
		2OG-FeII_Oxy	322..449	CDD:304390	49/178 (28%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	21/89 (24%)
		TPR	205..238		10/63 (16%)
		P4Hc	345..518	CDD:214780	47/172 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920