DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and PH4alphaNE2

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	135/534 - (25%)
Similarity:	227/534 - (42%)	Gaps:	100/534 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ENNS---VYSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYV 73
            |||:   ...|:..:..:|.:|:..::|::.....||.|.|.::..:..: .:.:|.::...:..
  Fly    23 ENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVFKM-MKRRQEYKSSMEIF 86

  Fly    74 GNPINAFSLVRRTHQDLPKWHNYSQQIVGMEELFALEEIIAKVPDKKDMAYSLGEMHRIEQIYDL 138
            .|||:.|||:|....:...|..|.:..||.||||.::..:..:|...|...:...:.:::..|.:
  Fly    87 ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQATYQM 151

  Fly   139 EAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPEGNAEIINSILGD 203
            .:.::|:|.:.|.||:......||:|:|.|......:..|..|...:|:...:.:::....:|..
  Fly   152 FSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRG 216

  Fly   204 PKVNLYTLYAKSMLIFGMIKSNPSMTIAEAKKISYEALNKASLADIKSLLNELLSQTDDEIVYEM 268
            ||:      |....|.|.:         :.|:.::|...:|....:|      ||..|.||..|.
  Fly   217 PKL------ADLCRILGQV---------QMKQRNHEGALQAYQVALK------LSPHDPEIYEEY 260

  Fly   269 N--------------VNKTKPSDYE-----IGCRGQFLRRR---NHVCTYNFTITEFLKLAPLKQ 311
            .              :.:.|.:.:|     ..|.|:....|   |..|.||...:.||:|||:|.
  Fly   261 RILEKRDLTLSDIEPIEQDKDNSHERLVLPPCCSGRCQVPRNLSNLYCVYNHVTSPFLQLAPIKT 325

  Fly   312 EVLNWDPYIVIYHDVLNDDEIDKL----KNHL-----NDTDA-------------------VEVN 348
            |:|:.||::|:.||:::..|...:    |.|:     .|.||                   .:.|
  Fly   326 EILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYSSDFN 390

  Fly   349 PIEKRIFQRINELTRLSFEHSDQQIVSKNGP----RTH----KHKKEYLKG------TLLFFLNN 399
            ...|:|.:|:.:.|.|....::...|...|.    .||    ..:|....|      |.||:||.
  Fly   391 DTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGTSDRIATTLFYLNE 455

  Fly   400 VELGGAMVFPKLKISVFPQKGSCLFWHNTLDPR------SEPLECPVLQGNKRV----ITQKGAY 454
            |..||...||:|.::||||.||.|||:| ||.:      |....|||:.|:|.|    |...|..
  Fly   456 VRQGGGTYFPRLNLTVFPQPGSALFWYN-LDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQE 519

  Fly   455 NGRPMQYKKAKSNQ 468
            ..||.......||:
  Fly   520 FTRPCVESSLSSNE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	29/128 (23%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	50/178 (28%)
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	29/128 (23%)
		TPR repeat	175..200	CDD:276809	6/24 (25%)
		TPR_16	176..254	CDD:290168	18/98 (18%)
		TPR repeat	219..249	CDD:276809	7/50 (14%)
		TPR_2	220..253	CDD:285020	9/47 (19%)
		P4Hc	342..513	CDD:214780	48/171 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900