DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and PH4alphaSG2

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	117/526 - (22%)
Similarity:	222/526 - (42%)	Gaps:	137/526 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VENNSVYSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSV--DYEFQQSFEDREKYV 73
            |.|...|||:..:..|.::||..:...::|.....:::...:.|::.:  ::|:..|....:.|:
  Fly    20 VANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATSQLKLDDYL 84

  Fly    74 GNPINAFSLVRRTHQDLPKWHNYSQQIV----GMEELFALEEIIAK---VPDKKDMAYSLGEMHR 131
            |:|::||.|::|..:|   |.:...:.:    ..||..|..|::::   .||:.::..::..:.|
  Fly    85 GHPLHAFRLIKRLVRD---WDSLIFEPILANNAREEFRAFVEVLSRDLGYPDQSELQGAIKGLAR 146

  Fly   132 IEQIYDLEAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVA---IKHEPEGN 193
            ::::|:|...:||.|.|.|..|......|:|..:|...|...:|||:..|.:||   :::.|...
  Fly   147 LQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQVAFILLRNSPREE 211

  Fly   194 -------------AEIINSILGDPKVNLYTLYAKSMLIFGMIKSNPSMTIAEAKKISYEALNKAS 245
                         |.:.|..||:||       ..:.|:..:::|.|:.:..:.:|.
  Fly   212 KDADHYLSDIREYASMANFELGNPK-------KAARLLSQILESQPTHSAQQTQKY--------- 260

  Fly   246 LADIKSLLNELLSQTDDEIVYEMNVNKTKP---SDYEIGCRGQ-------------FLRRRNHVC 294
                      |.|:...:     ||.:|||   |:|...|:|:             :|..:.|.
  Fly   261 ----------LESRVPGK-----NVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGKRHA- 309

  Fly   295 TYNFTITEFLKLAPLKQEVLNWDPYIVIYHDVLNDDEIDKLKNHLNDTDAVEV------------ 347
                    :..||||:.|.::.||.|.:||.:|:..:|..:   ..:.|..|:
  Fly   310 --------YFTLAPLQVEPVHLDPDINVYHGMLSSKQILSI---FEEADKEEMVRSAVAGSGGEG 363

  Fly   348 ----------------NPIEK---RIFQRINELTRLSFEHSDQQIVSKNGPRTHKHKKEYLK--- 390
                            :|:..   ||.|.::.......||  .|:.:......::...:|.:
  Fly   364 TVRDLRVSQQTWLDYKSPVMNSVGRIIQFVSGFDMAGAEH--MQVANYGVGGQYEPHPDYFEVNL 426

  Fly   391 ---------GTLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNT-----LDPRSEPLECPVL 441
                     .|.:|:|::||.||..||.||.:.:.|.||:.:.|||.     :|.|:....|||:
  Fly   427 PKNFEGDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVI 491

  Fly   442 QGNKRV 447
            .|:||:
  Fly   492 VGSKRI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	29/137 (21%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	39/174 (22%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	29/137 (21%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	36/168 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461892
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900