DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and PH4alphaSG1

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	141/530 - (26%)
Similarity:	220/530 - (41%)	Gaps:	126/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NNSVYSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPI 77
            |...||:|:.|.:||::|...:.....|..:..::.:||:.::|.:| |.|....|.|:|.||||
  Fly    17 NGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQID-EQQNDRGDLEEYFGNPI 80

  Fly    78 NAFSLVRR-THQ----------DLPKWHNYSQQIVGMEELFALEEIIAKVPDKKDMAYSLGEMHR 131
            |||..::| .|.          |...:..|...:..     :||:|..|.|.::|:..:...:.|
  Fly    81 NAFITIKRLVHDWKFNVFDPVFDSSNFETYKNNLSD-----SLEKINFKGPTQEDLHGATRALLR 140

  Fly   132 IEQIYDLEAIELARGRIQ-GKQYDFRPSI--RDCVALGEHKFKREDYQRASMWFRVAIKHEPEGN 193
            ::.:|.|....||.|.:. |::.....|:  .||..||::..:.::|...|.|...|.|.
  Fly   141 LQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLLEARKR----- 200

  Fly   194 AEIINSILGDPKVNLYTLYAKSMLIFGMIKSNPS-MTIAEAKKISYEALNKASLADIKSLLNELL 257
                             |:.|.:   |.|..|.| :.|.|....::..|....||  ..|.||:|
  Fly   201 -----------------LHGKPL---GFISPNVSDVEILEHLSSAFNGLGNLKLA--YKLNNEIL 243

  Fly   258 SQTDD-------EIVYEMNV------------------NKTKPSDYEI---GCRGQF----LRRR 290
            .:..|       :|:||..:                  .|.:...|::   .|||:.    ..:|
  Fly   244 DKKPDHEEALKNKILYEGQLARERSFAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQR 308

  Fly   291 NHVCTYNFTITEFLKLAPLKQEVLNWDPYIVIYHDVLNDDEIDKLKNH-------------LNDT 342
            |..|........:.:|:|.|.|.||.|||:...|:||.|.|||.:..|             .|.|
  Fly   309 NLRCWLYHQGVPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENST 373

  Fly   343 DA-----------VEVNPIEKRIFQRINELTRLSFEHSDQ----------------QIVSKNGPR 380
            .:           .:.||...:|.||:.::|.||.|.::.                ..|..:|..
  Fly   374 TSEVRISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQS 438

  Fly   381 THKHKKEYLKGTLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNT-----LDPRSEPLECPV 440
            ....|...|. |.||:||:|.||||..||.|:::|.|.|||.|.|:|.     .|.|::...|||
  Fly   439 VFSWKGNRLL-TALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPV 502

  Fly   441 LQGNKRVITQ 450
            |||:|.:..:
  Fly   503 LQGSKWICNE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	38/139 (27%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	53/171 (31%)
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	38/139 (27%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	50/167 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461956
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900