DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and CG31524

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	131/521 - (25%)
Similarity:	226/521 - (43%)	Gaps:	115/521 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEF-----QQSFEDREKYVGNPIN 78
            |:..:..||.||:..::.::.|..||:.|...::..|..:..:.     :|||:        ..|
  Fly    31 SVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMREQLDKSKKEQSFD--------LFN 87

  Fly    79 AFSLVRRTHQDLPKWHNYSQQIVGMEELFALEEIIAKVPDKKDMAYSLGEMHRIEQIYDLEAIEL 143
            .:|.:|....|...|..|..:.|..:||...:....::|.:.|:..:...:.|::..|.:.:.::
  Fly    88 RYSFIRHMQADWLMWKQYLDKPVIRDELNYKQMDNLRMPQELDLFDASEAIRRMQATYAMLSNDI 152

  Fly   144 ARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIK-HEPEGNAEIINSILGDPKVN 207
            |.|.:.|.||..:.|..||:|:|.|...:..:..|..|....|| .:.:|....:..:.|..|..
  Fly   153 AEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQWILAGIKAQDRKGPQTEMILLRGPTKAE 217

  Fly   208 LYTLYAKSMLIF------GMIKSNPSMTIAEAKKISYEALNKASLADI------KSLLNELLSQT 260
            |:....|  :.|      |.:|             :|:|..|.|..|:      ::|...:|:.:
  Fly   218 LFRTLGK--VRFERRNEEGALK-------------AYQAALKHSPHDLEIFQEYQNLKRRVLTLS 267

  Fly   261 DDEIVYEMNVNKTKPSD----YEI------GCRGQFLRRRNHV-CTYNFTITEFLKLAPLKQEVL 314
            ..|.:.|      :|:|    .|:      .|.|.  |:.|.: |.||.....||:|||:|.|:|
  Fly   268 PSEPIRE------EPNDDIEEMELPPCCSGRCEGP--RKLNRLYCVYNCVTAPFLRLAPIKTEIL 324

  Fly   315 NWDPYIVIYHDVL-------------------------NDDEIDKLKNHLN---DTDAVEVNPIE 351
            :.||::::.||::                         |:.||.|.:...:   |:||   |...
  Fly   325 SVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVNAANEFEIAKFRTSKSVWFDSDA---NEAT 386

  Fly   352 KRIFQRINELTRLSFEHSDQ-QIVSKN-GPRTHKH-------KKEYLKG------TLLFFLNNVE 401
            .::.||:.|.|.|..:||:. |:::.. |.....|       :..::.|      |.||:||:|.
  Fly   387 LKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADEDRFVNGYIDRLATTLFYLNDVP 451

  Fly   402 LGGAMVFPKLKISVFPQKGSCLFWHN-----TLDPRSEPLECPVLQGNKRVITQ----KGAYNGR 457
            .|||..||.|.|:|||:.|:.|.|:|     .|..|:....|||:.|:|.|:::    ||....|
  Fly   452 QGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSKWIDDKGQEFRR 516

  Fly   458 P 458
            |
  Fly   517 P 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	28/133 (21%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	49/174 (28%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	28/133 (21%)
		TPR_11	215..>259	CDD:290150	11/58 (19%)
		TPR_2	216..249	CDD:285020	9/47 (19%)
		P4Hc	340..507	CDD:214780	47/169 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461904
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900