DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18231 and P4ha2

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_006532515.1	Gene:	P4ha2 / 18452	MGIID:	894286	Length:	557	Species:	Mus musculus

Alignment Length:	546	Identity:	126/546 - (23%)
Similarity:	226/546 - (41%)	Gaps:	151/546 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPINAFS 81
            ::||..:..|:..|:..:.::|.|......|:..::::...::....:|..|.|.|:.:|:||:.
Mouse    26 FTSIGHMTDLIYAEKDLVQSLKEYILVEEAKLAKIKSWASKMEALTSRSAADPEGYLAHPVNAYK 90

  Fly    82 LVRRTHQDLPKWHNYSQQIVGMEELFALEEIIAK----------------VPDKKDMAYSLGEMH 130
            ||:|.:.|.|                ||.:::.:                .|..:|.:.:...:.
Mouse    91 LVKRLNTDWP----------------ALGDLVLQDASAGFVANLSVQRQFFPTDEDESGAARALM 139

  Fly   131 RIEQIYDLEAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPEG-NA 194
            |::..|.|:...::||.:.|.:|....|:.||..||...:...||....:|....:|....| .|
Mouse   140 RLQDTYKLDPDTISRGELPGTKYQAMLSVDDCFGLGRSAYNEGDYYHTVLWMEQVLKQLDAGEEA 204

  Fly   195 EIINSILGDPKVNLYTLYAKSMLIFG-----------MIKSNPSMTIAEAKKISYEALNKASLAD 248
            .:..|::.|     |..||...|  |           ::..:||...|......:|.|.:....
Mouse   205 TVTKSLVLD-----YLSYAVFQL--GDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEERG- 261

  Fly   249 IKSLLNELLSQTDDEIVYEMNVNKTKPSD-------YEIGCRGQFL-----RRRNHVCTYNF--T 299
             |||.|    |||..:..:.|:.: :|:|       ||..|||:.:     |::...|.|:.  .
Mouse   262 -KSLSN----QTDAGLATQENLYE-RPTDYLPERDVYESLCRGEGVKLTPRRQKKLFCRYHHGNR 320

  Fly   300 ITEFLKLAPLKQEVLNWD-PYIVIYHDVLNDDEIDKLK--------------------------- 336
            :.:.| :||.|:|. .|| |:||.|:||::|:||:::|
Mouse   321 VPQLL-IAPFKEED-EWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRV 383

  Fly   337 ---NHLNDTDAVEVNPIEKRIFQRINELTRLSFEHSDQQIVSKNG------PRTHKHKKEYLKG- 391
               :.|.:.|    :|:..|:.:|:..:|.|:.:.::...|:..|      |.....::.:..|
Mouse   384 SKSSWLEEDD----DPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRRPFDSGL 444

  Fly   392 ------------------------------TLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWH 426
                                          |.|.::::||.|||.|||.|..:::|:||:.:||:
Mouse   445 KTEGNRLATFLNYSDEQDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWY 509

  Fly   427 NTL-----DPRSEPLECPVLQGNKRV 447
            |.|     |.|:....||||.|.|.|
Mouse   510 NLLRSGEGDYRTRHAACPVLVGCKWV 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	28/144 (19%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	45/198 (23%)
P4ha2	XP_006532515.1	P4Ha_N	28..157	CDD:369820	28/144 (19%)
P4ha2	XP_006532515.1	P4Hc	348..541	CDD:214780	42/192 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920