DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18231 and phy-2

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_502317.1	Gene:	phy-2 / 178170	WormBaseID:	WBGene00004025	Length:	539	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	129/520 - (24%)
Similarity:	223/520 - (42%)	Gaps:	97/520 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VYSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPINAF 80
            ::::|..|..:|..|:...|.|..|......::.:|:.|.....:....:.....::|.|||||:
Worm    18 LFTAIADLQHMLGAEKDVTTIIDQYIEAERARLDDLRRYAHEYVHRNAHAESVGPEFVTNPINAY 82

  Fly    81 SLVRRTHQDLPKWHNYSQQIVGMEELFALEEII-------AKVPDKKDMAYSLGEMHRIEQIYDL 138
            .|::|.   ..:|......::..:....|:.|.       .|.|.::|::.:...:.|::..|.|
Worm    83 LLIKRL---TTEWKKVENIMLNNKASTFLKNITDNRVRSEVKFPGEEDLSGAATALLRLQDTYSL 144

  Fly   139 EAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVA-IKHEPEG-----NAEII 197
            :.::|:.|.|.|::...:.|..|...:|...:.::||....||.:|| :|.|.|.     ..||:
Worm   145 DTLDLSNGIIGGEKVSNKLSGHDTFEVGRSAYNQKDYYHCLMWMQVALVKIENENPPTIEEWEIL 209

  Fly   198 NSILGDPKVNLYTLYAKS------MLIFGMIKSNPSMTIAEAKKISYEAL--NKASLADIKSLLN 254
            ..:       .|:||.:.      .|...:.|..|:...|:.....||.:  .|..:.|:..::|
Worm   210 EYL-------AYSLYQQGNVRRALSLTKRLAKIAPNHPRAKGNVKWYEDMLQGKDMVGDLPPIVN 267

  Fly   255 ELLSQTDDEIVYEMNVNKTKPSDYEIGCRGQF----LRRRNHVCTYNFTITEFLKLAPLKQEVLN 315
            :       .:.|:..|.:   ..||..|||:.    .:.:|.:..|......||||||:|.|:|.
Worm   268 K-------RVEYDGIVER---DAYEALCRGEIPPVEPKWKNKLRCYLKRDKPFLKLAPIKVEILR 322

  Fly   316 WDPYIVIYHDVLNDDEIDKLKN-----------HLNDTDAVE---------------VNPIEKRI 354
            :||..|::.:|::|.||:.:|.           ..:.|..:|               ::|:..|:
Worm   323 FDPLAVLFKNVIHDSEIEVIKELASPKLKRATVQNSKTGELEHATYRISKSAWLKGDLDPVIDRV 387

  Fly   355 FQRINELTRLSFEHSDQQIVSKNGPRTH---------KHKKEYLK--------GTLLFFLNNVEL 402
            .:||.:.|.|:...|::..|:..|...|         |.:|...|        .|:||:::..|.
Worm   388 NRRIEDFTNLNQATSEELQVANYGLGGHYDPHFDFARKEEKNAFKTLNTGNRIATVLFYMSQPER 452

  Fly   403 GGAMVFPKLKISVFPQKGSCLFWHNTL-----DPRSEPLECPVLQGNKRV----ITQKGAYNGRP 458
            |||.||..|..:|||.|...|||:|..     |.|:....||||.|.|.|    |.:||....||
Worm   453 GGATVFNHLGTAVFPSKNDALFWYNLRRDGEGDLRTRHAACPVLLGVKWVSNKWIHEKGQEFTRP 517

Fly 459 458
Worm 518 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	28/135 (21%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	47/178 (26%)
phy-2	NP_502317.1	P4Ha_N	21..154	CDD:285528	28/135 (21%)
		TPR_16	169..240	CDD:290168	18/77 (23%)
		P4Hc	335..508	CDD:214780	46/172 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920