DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and p4ha1

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	531	Identity:	126/531 - (23%)
Similarity:	228/531 - (42%)	Gaps:	121/531 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPINAFS 81
            ::||..::.||..|:..:|::|.|.....:|:..::.:.|.:|:....:.:|.|.|:|:|:|||.
Frog    21 FTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTATKDPEGYLGHPVNAFK 85

  Fly    82 LVRRTHQDLPKWHNYSQQIVGMEELFALEEIIAK----------------VPDKKDMAYSLGEMH 130
            |::|.:.:..|                ||.:|.|                .|:.:|...:...:.
Frog    86 LMKRLNTEWVK----------------LENLILKDISDGFISNLTIQRQYFPNDEDQTGAAKALL 134

  Fly   131 RIEQIYDLEAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPEGNAE 195
            |::..|:|:...:::|.:.|.::....:..||..||:..:...||....:|...|:.....|...
Frog   135 RLQDTYNLDTDTISKGNLPGVKHKTSLTAEDCFDLGKTAYTDADYYHTELWMEQALSQLDAGEES 199

  Fly   196 IINSILGDPKVNLYTLYAKSMLIFGMIKSNPSMTI--------AEAKKISYEALNKASLADIKSL 252
            .::.::....:: |.:|.:..|...:..:..|:.:        ...:.|..:..||:|.:..:..
Frog   200 SLDKVMVLDYLS-YAVYQQGDLDKALTLTKRSLELDPEHQRGNGNLRHIMSKESNKSSSSPSEGA 263

  Fly   253 LNELLSQTDDEIVYEMNVNKTKPSD------YEIGCRGQFL-----RRRNHVCTY-NFTITEFLK 305
                          |:...|.:|.|      ||..|||:.:     |::...|.| :......|.
Frog   264 --------------ELRTRKGRPKDHLEKEKYEKLCRGEGVKMTSRRQKRLFCRYFDGKKDPLLI 314

  Fly   306 LAPLKQEVLNWD-PYIVIYHDVLNDDEIDKLKNHLND-----------TDAVEV----------- 347
            |:|.|||. .|| |.||.|||:::|:||.|:|.....           |..:|.
Frog   315 LSPTKQED-EWDKPRIVRYHDIISDEEISKVKELAKPRLRRATISNPITGVLETAQYRITKSAWL 378

  Fly   348 ----NPIEKRIFQRINELTRLSFEHSDQQIVSKNG------PR---THKHKKEYLK--------G 391
                :|:..|:.:||..:|.|....:::..|:..|      |.   ..|::.:..|        .
Frog   379 SGYEDPVVARLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDFLRKYEPDAFKKLGTGNRVA 443

  Fly   392 TLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNTL-----DPRSEPLECPVLQGNKRV---- 447
            |.||::::||.|||.|||::..:|:|:||:.:||:|.|     |..:....||||.|||.|
Frog   444 TWLFYMSDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVGNKWVSNKW 508

  Fly   448 ITQKGAYNGRP 458
            |.::|....||
Frog   509 IHERGQEFRRP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	32/144 (22%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	49/178 (28%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	25/102 (25%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	46/172 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110