DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18231 and p4ha1b

DIOPT Version :9

Sequence 1:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_999856.1	Gene:	p4ha1b / 100003675	ZFINID:	ZDB-GENE-030131-4089	Length:	536	Species:	Danio rerio

Alignment Length:	540	Identity:	131/540 - (24%)
Similarity:	229/540 - (42%)	Gaps:	122/540 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NNSVYSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPI 77
            :|..::|..::..||..|:..:|::|.|..:...:::.::.:.|.:|.....:.:|.|.::|:|:
Zfish    18 HNDFFTSTGQMTDLLYAEKDLVTSLKEYIKQEENRLEQVKEWADKLDSLTITATQDPEGFLGHPV 82

  Fly    78 NAFSLVRRTHQDLPKWHNYSQQIVGMEELFALEEIIAK----------------VPDKKDMAYSL 126
            |||.|::|.:.:   |.:             ||.::.|                .|..:|...:.
Zfish    83 NAFKLMKRLNSE---WSD-------------LENLVLKDTTNGFISNLTVQRQYFPTDEDQTGAA 131

  Fly   127 GEMHRIEQIYDLEAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPE 191
            ..:.|::..|.|.|..::.|.:.|..:..|.::.||..||:..:...||....:|...|:....|
Zfish   132 KALLRLQDTYQLSANAISSGDLPGVVHKSRMTVEDCYELGKIAYSDADYYHTELWMAQALSQLDE 196

  Fly   192 GNAEIINSILGDPKVNL-----YTLYAKS------MLIFGMIKSNPSMTIAEAKKISYE-ALNKA 244
            |....|:      ||.:     |.:|.:.      .|...|:|.:|:...|......:| .|.|.
Zfish   197 GEESPID------KVTVMDYLSYAIYQQGELDRALELTKRMLKLDPNHHRANGNLKYFEFQLEKQ 255

  Fly   245 SLADIKSLLNELLSQTDDEIVYEMNVNKTKPSD-------YEIGCRGQFL----RRRNHV-CTY- 296
            ..|:     ||...:....::.:.:..:.:..|       ||..|||:.:    ||::.: |.|
Zfish   256 RKAE-----NEKKEEDQKRVLDKRDAQRKRSKDPLPERKKYERLCRGEGIKLTPRRQSRLFCRYS 315

  Fly   297 NFTITEFLKLAPLKQEVLNWD-PYIVIYHDVLNDDEIDKLKNHLND-----------TDAVEVNP 349
            |......|.|||:|||. .|| |.||.||::::|.||:.:|.....           |..:|..|
Zfish   316 NNNRNPRLLLAPVKQED-EWDRPRIVRYHEIISDSEIETVKEMAKPRLRRATISNPITGVLETAP 379

  Fly   350 IE---------------KRIFQRINELTRLSFEHSDQQIVSKNG------PR---THKHKKEYLK 390
            ..               :||.|||.::|.|..:.:::..|:..|      |.   ..|.:.:..|
Zfish   380 YRISKSAWLSGYEHSTIERINQRIEDVTGLEMDTAEELQVANYGVGGQYEPHFDFGRKDEPDAFK 444

  Fly   391 --------GTLLFFLNNVELGGAMVFPKLKISVFPQKGSCLFWHNTL-----DPRSEPLECPVLQ 442
                    .|.||::::|..|||.||..:..:|:|:||:.:||:|..     |..:....||||.
Zfish   445 ELGTGNRIATWLFYMSDVSAGGATVFTDVGAAVWPKKGTAVFWYNLFPSGEGDYSTRHAACPVLV 509

  Fly   443 GNKRV----ITQKGAYNGRP 458
            |||.|    |.::|....||
Zfish   510 GNKWVSNKWIHERGQEFRRP 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	29/144 (20%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	46/178 (26%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	29/144 (20%)
		TPR repeat	164..199	CDD:276809	10/34 (29%)
		TPR_16	168..238	CDD:290168	17/75 (23%)
		TPR repeat	204..234	CDD:276809	6/29 (21%)
		P4Hc	347..520	CDD:214780	44/172 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920