DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18233 and P4HA2

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens

Alignment Length:	527	Identity:	147/527 - (27%)
Similarity:	262/527 - (49%)	Gaps:	69/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNEREKFVSNPLNAF 95
            :.:|:..:..|:..|:|.:.:...|..:.:.|:..:..:.:.::....|:..:.|.::::|:||:
Human    23 FFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAY 87

  Fly    96 GLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSAA-------------PESFDMNEKLKAMHRI 147
            .|::|||.|||.|::           ..:||  |||             |...|.....||:.|:
Human    88 KLVKRLNTDWPALED-----------LVLQD--SAAGFIANLSVQRQFFPTDEDEIGAAKALMRL 139

  Fly   148 ETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALKLSTDGSLEIM 212
            :.||.|.|..|::|.|..|::...|...||..:....:..|::..::||.::.||....|.....
Human   140 QDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATT 204

  Fly   213 NRLKEIELKGFAT---AVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDLEQLISSELKQWIND 274
            .:.:.::...:|.   ....|::.|:.:.|:.:...:.|...|:     ..|||:..|.::.:.:
Human   205 TKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLR-----YFEQLLEEEREKTLTN 264

  Fly   275 DS----TTP------PTDH--------NLGCRG----LFPKK-SNLVCRYNSSTNA-FLKLAPLK 315
            .:    .||      |.|:        :| |||    |.|:: ..|.|||:....| .|.:||.|
Human   265 QTEAELATPEGIYERPVDYLPERDVYESL-CRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFK 328

  Fly   316 MEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDPKE--------IVSRVYWIRKESS 372
            .|:....|:||.:::|:||::||.:| ||.:.:....::.|||.        .||:..|:.::..
Human   329 EEDEWDSPHIVRYYDVMSDEEIERIK-EIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDD 392

  Fly   373 -FSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDVNNTLGDRIGSIIFY 436
             ...|:|:|:..:||..::....:|:||:||||.::||:||..:..::...:...|:|:.:.:.|
Human   393 PVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNY 457

  Fly   437 AGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAP 501
            ..:|..||.||||||..|:.||||.|:||:|.......|.|:.|:.||||||.:|...||.|...
Human   458 MSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERG 522

  Fly   502 QLFVKPC 508
            |.|::||
Human   523 QEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	35/141 (25%)
		ATP-synt_B	<198..278	CDD:304375	13/86 (15%)
		P4Hc	333..498	CDD:214780	62/173 (36%)
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	35/141 (25%)
		TPR	207..240		4/32 (13%)
		P4Hc	346..519	CDD:214780	62/173 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020