DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18233 and p4ha1a

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	547	Identity:	157/547 - (28%)
Similarity:	267/547 - (48%)	Gaps:	58/547 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VRAAAVLILVQSIHSTDP-NDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNI 68
            ||:....:|:..:.|:.. :||.      :|:..:..||..|::.:.:...|....:.|::.:..
Zfish     4 VRSVCCFLLISLLKSSSAHSDFF------TSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQ 62

  Fly    69 FLDALKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLG---LEQLTAMQDIVSA 130
            :.:.|.........:.|.|:.:|:|||.|::|||.:|.::::...|.:.   :..||..:...
Zfish    63 WAEKLDALTATAVQDPEGFLGHPVNAFKLMKRLNTEWGEVEDLVLKDMSDGFISNLTIQRQYF-- 125

  Fly   131 APESFDMNEKLKAMHRIETTYDLQPKDIAKGLLQ--RTEFNYR--LLFRDCLALAYHKFEIGEFK 191
             |...|.|...||:.|::.||.|..:.|:.|.|.  .|...|:  |...||..|....:...::.
Zfish   126 -PNDEDQNGAAKALLRLQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYY 189

  Fly   192 RSLLWFQEALKLSTDG---SLEIMNRLKEIELKGFATAVAKRSIYLSNQGLTNETIDDMA----- 248
            .:.||..:|||...:|   |:||...|..:....:.....:|::..:.:.||.|.....|
Zfish   190 HTELWMAQALKQLDEGEESSVEIATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRALGNLK 254

  Fly   249 --NSQLQDAKLMDLEQLISSELKQWINDDSTTPPTDHNLG--------CRG----LFPKK-SNLV 298
              :.||...|..:.||....|.|:   :..|:......|.        |||    :.|:: .:|.
Zfish   255 YFDYQLAKQKKAEKEQSTKEESKK---EQETSDGKKEYLPEKRKYEKLCRGEGLKMTPRRQKHLF 316

  Fly   299 CRY-NSSTNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDP----- 357
            ||| |.:.:.|..:.|:|.|:....|.|:.:||:|::::||::| |:::......::.:|
Zfish   317 CRYFNGNRHPFYTIGPVKQEDEWDRPRIIRYHEIITEQEIEKIK-ELSKPRLRRATISNPITGVL 380

  Fly   358 ---KEIVSRVYWIRK-ESSFSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLK 418
               ...:|:..|:.. |.....||||||.|:||..::....:|:||:||||.::||:||  .|..
Zfish   381 ETAHYRISKSAWLAAYEHPVVDRINQRIEDITGLNVKTAEELQVANYGVGGQYEPHFDF--GRKD 443

  Fly   419 EVDVNNTL--GDRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHS 481
            |.|....|  |:||.:.:||..:|:.||.||||::..||:|.||.|:||:|.|.....|..:.|:
Zfish   444 EPDAFKELGTGNRIATWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSGEGDYSTRHA 508

  Fly   482 VCPVLVGSRWTITKWLHYAPQLFVKPC 508
            .||||||::|...||:|...|.|.:||
Zfish   509 ACPVLVGNKWVSNKWIHERGQEFRRPC 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	32/131 (24%)
		ATP-synt_B	<198..278	CDD:304375	20/89 (22%)
		P4Hc	333..498	CDD:214780	65/175 (37%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	32/131 (24%)
		TPR repeat	172..207	CDD:276809	9/34 (26%)
		TPR repeat	212..242	CDD:276809	4/29 (14%)
		Fis1	218..262	CDD:304536	7/43 (16%)
		P4Hc	352..525	CDD:214780	65/175 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850