DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18233 and P4HA1

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_000908.2	Gene:	P4HA1 / 5033	HGNCID:	8546	Length:	534	Species:	Homo sapiens

Alignment Length:	553	Identity:	159/553 - (28%)
Similarity:	266/553 - (48%)	Gaps:	87/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKR 75
            ::|.||:  ..|..|       :|:..:..|:..|::.:.:...|....::|::.:..:.:.|.|
Human    10 ILLPQSL--AHPGFF-------TSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    76 PNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLG---LEQLTAMQDIVSAAPESFDM 137
            .......:.|.||.:|:|||.|::|||.:|.:|:|...|.:.   :..||..:...   |...|.
Human    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYF---PNDEDQ 127

  Fly   138 NEKLKAMHRIETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALK 202
            ....||:.|::.||:|....|:||.|...:....|...||..|....:...::..:.||.::||:
Human   128 VGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALR 192

  Fly   203 LSTDGSLEIMNRLKEIELKGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDLE---QLI 264
            ...:|.:..::::..::...:|       :|  .||       |:..:.|...||::|:   |..
Human   193 QLDEGEISTIDKVSVLDYLSYA-------VY--QQG-------DLDKALLLTKKLLELDPEHQRA 241

  Fly   265 SSELK--QWI---------------NDDSTTPP------------TDHNLGCRG----LFPKK-S 295
            :..||  ::|               :|..|||.            ..:.:.|||    :.|:: .
Human   242 NGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQK 306

  Fly   296 NLVCRY-NSSTNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDPKE 359
            .|.||| :.:.|....|||.|.|:....|.|:.||::|||.:||.:| ::.:......::.||:.
Human   307 KLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVK-DLAKPRLSRATVHDPET 370

  Fly   360 --------IVSRVYWIR-KESSFSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDF--- 412
                    .||:..|:. .|:....|||.||.|:||..:.....:|:||:||||.::||:||
Human   371 GKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARK 435

  Fly   413 -YTDRLKEVDVNNTLGDRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDP 476
             ..|..||:..    |:||.:.:||..:||.||.||||::..:|.||||.|:||:|.|.....|.
Human   436 DEPDAFKELGT----GNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDY 496

  Fly   477 RSLHSVCPVLVGSRWTITKWLHYAPQLFVKPCS 509
            .:.|:.||||||::|...||||...|.|.:||:
Human   497 STRHAACPVLVGNKWVSNKWLHERGQEFRRPCT 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	35/131 (27%)
		ATP-synt_B	<198..278	CDD:304375	17/99 (17%)
		P4Hc	333..498	CDD:214780	67/177 (38%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	21/86 (24%)
		TPR	205..238		9/48 (19%)
		P4Hc	345..518	CDD:214780	67/177 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870