DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18233 and CG9698

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	151/555 - (27%)
Similarity:	267/555 - (48%)	Gaps:	76/555 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLNVVRAAAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDN 65
            |:..|.:...|:..|:|.|....:|.      ||:..:.|:...||:.:::...:.:..|:|:|
  Fly     1 MIFPVFSVLFLLFHQAIPSVSGVEFF------SSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLD- 58

  Fly    66 LNIFLDALKRPNHKTHNE-RE---KFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQD 126
               ||.|..|......|| ||   .:..:|:|.:.|.:||..||.:::|......|.:.||.::.
  Fly    59 ---FLKARLREFENERNEAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPLTRLRK 120

  Fly   127 IVS--AAPESFDMNEKLKAMHRIETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGE 189
            ..:  ..|:..::...:..:.|::..|.|:.||:|:|:|...::..:|....|:.:|........
  Fly   121 FRNRETMPDKKELEGAIDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRDQH 185

  Fly   190 FKRSLLWFQEALKLSTDGSLEIMNRLKEIELKGFATAV---AKRSIYLSNQGLTNETIDDMANSQ 251
            .:.:..|..||....|.|.       ||.:||....|:   ||:.:. ..:|| |:|..::...|
  Fly   186 PRLAHSWLIEANDRLTGGE-------KEEQLKPQILALLVQAKKELE-DFRGL-NDTYQELIGIQ 241

  Fly   252 -LQDAKLMDLEQLIS--SELKQWINDDSTTPPTDH----------------NLGCRG---LFPKK 294
             ..:....:.|..::  || |..:|:  :.|..:|                :|.|.|   |.||:
  Fly   242 SASEEHAKNYETFLNALSE-KALLNE--SKPILEHAPIPEEGEPVGEFQAYSLTCSGHWRLTPKE 303

  Fly   295 S-NLVCRYNSSTNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITE---MENGWTSLG 355
            . :|.|.|.:.|:.||.:||||.||:.:||.:|::|:||...:|:.:: ::||   |....||..
  Fly   304 QRHLRCGYVTETHPFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIR-KLTENRLMRATITSHN 367

  Fly   356 DPKEIVSRVYWIRKESSFS----------KRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHY 410
            :  .:||.|    :.|.|:          ..|:||::|||...::.....|.||:|:||::..|.
  Fly   368 E--SVVSNV----RTSQFTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHM 426

  Fly   411 DFYTDRLKEVDVNNT--LGDRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDST 473
            |::.....:..:.::  :|:||.:::||..:|:|||.|.||.|:..::|||..|.||.|......
  Fly   427 DWFYQTTFDAGLVSSPEMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGV 491

  Fly   474 PDPRSLHSVCPVLVGSRWTITKWLHYAPQLFVKPC 508
            .|.|:.|..||::.||:|...:|:....|...:||
  Fly   492 GDVRTQHGACPIIAGSKWVQNRWIRENDQSDRRPC 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	34/134 (25%)
		ATP-synt_B	<198..278	CDD:304375	21/85 (25%)
		P4Hc	333..498	CDD:214780	54/179 (30%)
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	34/134 (25%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	54/177 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461864
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910