DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18233 and p4ha2

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	553	Identity:	158/553 - (28%)
Similarity:	268/553 - (48%)	Gaps:	69/553 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AAAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLD 71
            ||.::.|:.::..:.|    .|....:|:..:..|:..|:|.:.:...|....::|::.:..:.:
Zfish     2 AAFLVFLLSTLSFSSP----TRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWAN 62

  Fly    72 ALKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSAAPESFD 136
            .|.:....:.::.|.|:::|:||:.|::|||.:|.:|::...:......::.|.......|:..|
Zfish    63 KLDKLTRTSTSDPEGFLAHPVNAYKLMKRLNTEWSELESLVLQDPSDGFISNMSVHRQYFPDEED 127

  Fly   137 MNEKLKAMHRIETTYDLQPKDIAKGLL--QR----TEFNYRLLFRDCLALAYHKFEIGEFKRSLL 195
            .....||:.|::.||.|..:..:||.|  ||    ..:|..|...||..:....:...::..|:|
Zfish   128 EKGAAKALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSVL 192

  Fly   196 WFQEALKLSTDG------SLEIMNRLKEIELKGFATAVAKRSIYLSNQGLTNETIDDMANSQLQD 254
            |.|::|:....|      ..::::.|   ....:......|:|.|:.:.|   .||  .:.|...
Zfish   193 WMQQSLRQMDSGEEAKTPKADVLDYL---SYSVYQMGDLPRAIELTRRLL---AID--PSHQRAG 249

  Fly   255 AKLMDLEQLISSELKQWINDDSTTP-PTD---------------------HNLGCRG-----LFP 292
            ..|...|:|:|.||:   :...|.| |.|                     :...|||     ...
Zfish   250 GNLRYFERLLSKELQ---DSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTTK 311

  Fly   293 KKSNLVCRY-NSSTNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGD 356
            ::|.|.||| :.:.|..|.|.|:|.|:....|:||.|.|.:||::|:::| ||...:....::.|
Zfish   312 RQSRLFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIK-EIATPKLARATVRD 375

  Fly   357 PKE--------IVSRVYWIRKESS-FSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDF 412
            ||.        .||:..|:..|.. ...|:||||.|:||..::....:|:||:||||.::||:||
Zfish   376 PKTGVLTVAHYRVSKSAWLEGEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDF 440

  Fly   413 YTDRLKEVDVNNTL--GDRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPD 475
              .|..|.|...:|  |:|:.:.:.|..:|..||.|||||...:|.|:||.|:||:|.|.....|
Zfish   441 --SRKDEPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGD 503

  Fly   476 PRSLHSVCPVLVGSRWTITKWLHYAPQLFVKPC 508
            .|:.|:.|||||||:|...||:|...|.|.:||
Zfish   504 YRTRHAACPVLVGSKWVSNKWIHERGQEFRRPC 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	29/128 (23%)
		ATP-synt_B	<198..278	CDD:304375	17/85 (20%)
		P4Hc	333..498	CDD:214780	69/175 (39%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	29/128 (23%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	69/175 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920