DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18233 and P4ha3

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	117/534 - (21%)
Similarity:	234/534 - (43%)	Gaps:	82/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RAAAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFL 70
            |.||:|:|:: :...||.....|:...|::..:.:.|..|:..:.....|....:.::.:|..|.
  Rat     6 RLAALLVLLE-LGVGDPAAAAGREDTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFY 69

  Fly    71 DALKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQD----IVSAA 131
            |.:.    ..|.:.:..|.|||.||.||:||..||   :|........|.:.|::|    :....
  Rat    70 DKVL----SLHEDLKIPVVNPLLAFTLIKRLQSDW---RNVVHSLEATENIRALKDGYEKVEQDL 127

  Fly   132 PESFDMNEKLKAMHRIETTYDLQPKDIAKGLLQRTE-------FNYRLLFR----DCLALAYHKF 185
            |...|:....:|:.|::..|.|..|.:|:|:.||..       ::.|.||.    ||..:....:
  Rat   128 PAFEDLEGAARALMRLQDVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAY 192

  Fly   186 EIGEFKRSLLWFQEALKL--------STDGSLEIMNRLKEIELKGFATAVAKRSIYLSNQGLTNE 242
            :.|::..::.|.:||:.|        .|:....:.:.|..:....:.......::.||.:.|...
  Rat   193 DTGDYYHAIPWLEEAVSLFRRSYGEWKTEDEASLEDALDYLAFACYQVGNVSCALSLSREFLVYS 257

  Fly   243 TIDD-MANSQL-------QDAKLMDLEQLISSELKQWINDDSTTPPTDHNLGCRGLFPKKSNLVC 299
            ..:. ||.:.|       ::..||..|..|.......:....|.......||.:....:..:|.|
  Rat   258 PDNKRMARNVLKYERLLAENGHLMAAETAIQRPNVPHLQTRDTYEGLCQTLGSQPTHYQIPSLYC 322

  Fly   300 RYNSSTNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITE--MENGWTSLGDPKEI-- 360
            .|.::::.:|.|.|.:.|.|...|.:.::|:.:||::.:::: |:.|  ::....:.|: |::
  Rat   323 SYETNSSPYLLLQPARKEVIHLRPLVALYHDFVSDEEAQKIR-ELAEPWLQRSVVASGE-KQLQV 385

  Fly   361 ---VSRVYWIRKE-SSFSKRINQRISDMTGFKLE----EFPAIQLANFGVGGYFKPHYDFYTD-- 415
               :|:..|::.. ......:::||:.:||..::    |:  :|:.|:|:||:::||:|..|.
  Rat   386 EYRISKSAWLKDTVDPVLVTLDRRIAALTGLDIQPPYAEY--LQVVNYGIGGHYEPHFDHATSPS 448

  Fly   416 ----RLKEVDVNNTLGDRIGSIIFYAGEVSQGGQTVFP----DLKVAVEPKKGNALFWFNAFDDS 472
                ::|.       |:|:.:::.|...|..||.|.|.    .:.|...|..|     :.:.|.:
  Rat   449 SPLYKMKS-------GNRVATLMIYLSSVEAGGATAFIYGNFSVPVVKWPTSG-----YTSMDRN 501

  Fly   473 TPDPRSLHSVCPVL 486
            :.||     ..|:|
  Rat   502 SEDP-----AAPIL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	32/132 (24%)
		ATP-synt_B	<198..278	CDD:304375	15/95 (16%)
		P4Hc	333..498	CDD:214780	39/176 (22%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	20/80 (25%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	30/132 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750