DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18233 and P4ha2

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	145/533 - (27%)
Similarity:	252/533 - (47%)	Gaps:	81/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNEREKFVSNPLNAF 95
            :.:|:..:..|:..|::.:.:...|....:.|:..:..:...::....|:..:.|.::::|:||:
  Rat    23 FFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNAY 87

  Fly    96 GLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSA-----------APESFDMNEKLKAMHRIET 149
            .|::|||.|||.|.:           ..:||..:.           .|...|.:...:|:.|::.
  Rat    88 KLVKRLNTDWPALGD-----------LVLQDAAAGFVANLSVQRQFFPTDEDESGAARALMRLQD 141

  Fly   150 TYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQEALKLSTDGSLEIMNR 214
            ||.|.|..|::|.|..|::...|...||..:....:..|::..::||.::.||....|  |....
  Rat   142 TYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAG--EEATV 204

  Fly   215 LKEIELKGFATAVAK-----RSIYLSNQGLTNETIDDMANSQLQDAKLMDLEQLISSELKQWIND 274
            .|.:.|...:.||.:     |::.|:.:.|:.:...:.|...|:     ..|:|:..|     ..
  Rat   205 TKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLR-----YFERLLEEE-----RG 259

  Fly   275 DSTTPPTDHNLG----------------------CRG----LFPKK-SNLVCRYNSSTNA-FLKL 311
            .|.:..||..|.                      |||    :.|:: ..|.|||:..... .|.:
  Rat   260 KSLSNQTDAGLASQENLYERPVDYLPERDVYESLCRGEGIKMTPRRQKRLFCRYHHGNRVPQLLI 324

  Fly   312 APLKMEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDPKE--------IVSRVYWIR 368
            ||.|.|:....|:||.:::|:||::||.:| ||.:.:....::.|||.        .||:..|:.
  Rat   325 APFKEEDEWDSPHIVRYYDVMSDEEIERIK-EIAKPKLARATVRDPKTGVLTVASYRVSKSSWLE 388

  Fly   369 KESS-FSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDVNNTL--GDRI 430
            ::.. ...|:|:|:..:||..::....:|:||:|:||.::||:||  .|..|.|....|  |:|:
  Rat   389 EDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDF--SRSDERDAFKRLGTGNRV 451

  Fly   431 GSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITK 495
            .:.:.|..:|..||.||||||..|:.||||.|:||:|.......|.|:.|:.||||||.:|...|
  Rat   452 ATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNK 516

  Fly   496 WLHYAPQLFVKPC 508
            |.|...|.|::||
  Rat   517 WFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	30/139 (22%)
		ATP-synt_B	<198..278	CDD:304375	17/84 (20%)
		P4Hc	333..498	CDD:214780	65/175 (37%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	17/87 (20%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	65/175 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920