DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18233 and PH4alphaSG1

DIOPT Version :9

Sequence 1:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	153/541 - (28%)
Similarity:	252/541 - (46%)	Gaps:	89/541 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDALKRPNHKTHNER---EKF 87
            :|..|| |::..|.:||.:|...:..|..|....|::.:||..|||.:    .:..|:|   |::
  Fly    16 VNGDYY-SAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQI----DEQQNDRGDLEEY 75

  Fly    88 VSNPLNAFGLIRRLNQDW------PKLQNYTQKPLGLEQLTAMQDIVSAAPESFDMNEKLKAMHR 146
            ..||:|||..|:||..||      |...:...:........:::.|....|...|::...:|:.|
  Fly    76 FGNPINAFITIKRLVHDWKFNVFDPVFDSSNFETYKNNLSDSLEKINFKGPTQEDLHGATRALLR 140

  Fly   147 IETTYDLQPKDIAKGLLQRTEFN---YRLLFRDCLALAYHKFEIGEFKRSLLWFQEALK------ 202
            ::..|.|....:|.|:|...|.|   ..|...||..|..:..||.|:.....|..||.|
  Fly   141 LQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLLEARKRLHGKP 205

  Fly   203 ---LSTDGS-LEIMNRLKEIELKGFATAVAKRSIYLSNQGLTNETIDD-------MANSQLQDAK 256
               :|.:.| :||:..|.. ...|..      ::.|:.: |.||.:|.       :.|..|.:.:
  Fly   206 LGFISPNVSDVEILEHLSS-AFNGLG------NLKLAYK-LNNEILDKKPDHEEALKNKILYEGQ 262

  Fly   257 L-----------MDLEQLISSELKQWINDDSTTPPTDHNL---GCRGLF---PKKS-NLVCRYNS 303
            |           ::|.|:...|.|:           .:.|   .|||..   |::. ||.|....
  Fly   263 LARERSFAPRKQVELPQIAEKEQKE-----------SYKLYTQVCRGELHQSPREQRNLRCWLYH 316

  Fly   304 STNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEM---------KGEITEMENGWTSLGDPKE 359
            ....:.:|:|.|:|:::.|||:...|||:.|.:|:.:         :.::.:.||..||     |
  Fly   317 QGVPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENSTTS-----E 376

  Fly   360 I-VSRVYWIRKESS-FSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDV 422
            : :||..|:..::: :..:|.||:.|:||...|....:||.|:|:||.::||:||..|  ....|
  Fly   377 VRISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVED--DGQSV 439

  Fly   423 NNTLGDRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLV 487
            .:..|:|:.:.:||..:|:.||.|.||.|::||.|.||:.|.|:|....:..|.|:.|:.||||.
  Fly   440 FSWKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQ 504

  Fly   488 GSRWTITKWLHYAPQLFVKPC 508
            ||:|...:|.|...|.|.:||
  Fly   505 GSKWICNEWFHVGAQEFRRPC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	35/137 (26%)
		ATP-synt_B	<198..278	CDD:304375	21/107 (20%)
		P4Hc	333..498	CDD:214780	59/175 (34%)
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	35/137 (26%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	59/174 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461955
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900